HitPredict

Interactor 1: FOXG1 (P55316)
Forkhead box protein G1 (Brain factor 1) (BF-1) (BF1) (Brain factor 2) (BF-2) (BF2) (hBF-2) (Forkhead box protein G1A) (Forkhead box protein G1B) (Forkhead box protein G1C) (Forkhead-related protein FKHL1) (HFK1) (Forkhead-related protein FKHL2) (HFK2) (Forkhead-related protein FKHL3) (HFK3)
Gene: FOXG1

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 489 Hs			1 1217
+	Hs
		877640 FOXG1_HUMAN (1-489): 9.66e-156: 453: 100.00		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		877611 FOXG1_HUMAN (1-489): 9.66e-156: 453: 100.00		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		1021181 FOXC1_HUMAN (142-271): 2.43e-47: 173: 50.77		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1021385 FOXL1_HUMAN (155-288): 2.31e-48: 171: 47.02		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1306885 FOXB1_HUMAN (169-452): 7.39e-48: 169: 27.82		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1021360 FOXL1_HUMAN (155-288): 2.31e-48: 171: 47.02		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		1021108 FOXC1_HUMAN (142-271): 2.43e-47: 173: 50.77		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		1306870 FOXB1_HUMAN (169-452): 7.39e-48: 169: 27.82		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		126482 FOXE1_HUMAN (105-269): 1.08e-46: 168: 41.82		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		1021284 FOXL1_HUMAN (155-288): 2.31e-48: 171: 47.02		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		1057370 FOXB1_HUMAN (169-452): 7.39e-48: 169: 27.82		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		311534 FOXL1_HUMAN (155-288): 2.31e-48: 171: 47.02		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		311512 FOXL2_HUMAN (131-270): 1.05e-47: 170: 48.57		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		311609 FOXB1_HUMAN (169-452): 7.39e-48: 169: 27.82		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		208882 FOXS1_HUMAN (165-416): 5.89e-46: 164: 33.46		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		528365 FOXA1_HUMAN (80-448): 8.86e-50: 178: 22.84		MYH6_HUMAN (479-1126): 5.08e-21: 102: 10.45