Protein: SL9A1
Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)

Gene: SL9A1, SLC9A1
Organism: Homo sapiens
Interactions: 121
UniProt ID: P19634

Gene Ontology (top 5):
GO:0005516 - calmodulin binding
GO:0005543 - phospholipid binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

624666

CHP1
Calcineurin B homologous protein 1

6

20

Small-scale

0.958

High

225742

CHP2
Calcineurin B homologous protein 2

4

20

Small-scale

0.920

High

624660

CHP3
Calcineurin B homologous protein 3

4

20

Small-scale

0.707

High

624659

LPAR1
Lysophosphatidic acid receptor 1

4

3

High-throughput

0.691

High

624607

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

3

High-throughput

0.667

High

375166

RASK
GTPase KRas

3

5

High-throughput

0.640

High

332617

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.638

High

624608

PI2R
Prostacyclin receptor

2

2

High-throughput

0.628

High

624643

GALT7
N-acetylgalactosaminyltransferase 7

2

5

High-throughput

0.628

High

624645

SO6A1
Solute carrier organic anion transporter family member 6A1

2

1

High-throughput

0.628

High

624651

FNDC5
Fibronectin type III domain-containing protein 5

2

2

High-throughput

0.628

High

624661

TECT2
Tectonic-2

2

1

High-throughput

0.628

High

624604

1433B
14-3-3 protein beta/alpha

2

8

Small-scale

0.611

High

624635

EREP1
Endosomal transmembrane epsin interactor 1

2

2

High-throughput

0.611

High

367567

CAH2
Carbonic anhydrase 2

2

0

Small-scale

0.607

High

276237

SEM7A
Semaphorin-7A

2

0

High-throughput

0.602

High

624190

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

2

0

High-throughput

0.602

High

624636

AOC3
Amine oxidase [copper-containing] 3

2

0

High-throughput

0.602

High

624658

CC107
Coiled-coil domain-containing protein 107

2

0

High-throughput

0.602

High

624675

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

373764

RASN
GTPase NRas

2

5

High-throughput

0.584

High

624623

RHOB
Rho-related GTP-binding protein RhoB

2

10

High-throughput

0.584

High

624665

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

5

Small-scale

0.578

High

417257

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.559

High

395473

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

348052

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

6

High-throughput

0.541

High

183907

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.536

High

332355

5HT3B
5-hydroxytryptamine receptor 3B

1

1

High-throughput

0.536

High

548414

MPRI
Cation-independent mannose-6-phosphate receptor

1

1

High-throughput

0.536

High

624606

OPRX
Nociceptin receptor

1

2

High-throughput

0.536

High

624615

CCR6
C-C chemokine receptor type 6

1

2

High-throughput

0.536

High

624629

IDD
Integral membrane protein DGCR2/IDD

1

7

High-throughput

0.536

High

624640

SO4C1
Solute carrier organic anion transporter family member 4C1

1

1

High-throughput

0.536

High

624654

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

5

High-throughput

0.536

High

624655

GP151
G-protein coupled receptor 151

1

3

High-throughput

0.536

High

624657

S20A1
Sodium-dependent phosphate transporter 1

1

1

High-throughput

0.536

High

624682

FPRP
Prostaglandin F2 receptor negative regulator

1

2

High-throughput

0.536

High

624684

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.529

High

624667

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

624610

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.515

High

624612

ARRB1
Beta-arrestin-1

1

3

Small-scale

0.515

High

378607

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

624627

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

624637

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

624638

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

624641

LRC55
Leucine-rich repeat-containing protein 55

1

0

High-throughput

0.513

High

624642

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.513

High

624648

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.513

High

624669

STRA6
Receptor for retinol uptake STRA6

1

0

High-throughput

0.513

High

624671

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

624677

CRLF2
Cytokine receptor-like factor 2

1

0

High-throughput

0.513

High

624687

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

High-throughput

0.513

High

624689

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

624688

AP4S1
AP-4 complex subunit sigma-1

1

3

High-throughput

0.489

High

387096

TNNC2
Troponin C, skeletal muscle

1

0

High-throughput

0.481

High

624672

WNK1
Serine/threonine-protein kinase WNK1

1

2

High-throughput

0.481

High

213804

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.480

High

126460

RHOD
Rho-related GTP-binding protein RhoD

1

12

High-throughput

0.479

High

189412

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

340980

DIRA3
GTP-binding protein Di-Ras3

1

1

High-throughput

0.479

High

374391

RASH
GTPase HRas

1

2

High-throughput

0.479

High

466104

RHOC
Rho-related GTP-binding protein RhoC

1

8

High-throughput

0.479

High

555864

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

580870

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

601169

RHOQ
Rho-related GTP-binding protein RhoQ

1

10

High-throughput

0.479

High

624603

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

624605

HSP74
Heat shock 70 kDa protein 4

1

11

Small-scale

0.479

High

624611

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

624613

EMD
Emerin

1

2

High-throughput

0.479

High

624614

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

624616

RND2
Rho-related GTP-binding protein RhoN

1

10

High-throughput

0.479

High

624617

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

624618

RAC3
Ras-related C3 botulinum toxin substrate 3

1

9

High-throughput

0.479

High

624619

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

624620

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

624621

RHOA
Transforming protein RhoA

1

9

High-throughput

0.479

High

624622

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

624624

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

624628

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.479

High

624631

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

624632

ROCK1
Rho-associated protein kinase 1

1

4

Small-scale

0.479

High

624634

RHOH
Rho-related GTP-binding protein RhoH

1

10

High-throughput

0.479

High

624639

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

624644

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.479

High

624653

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

624663

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

624673

RHOJ
Rho-related GTP-binding protein RhoJ

1

10

High-throughput

0.479

High

624676

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

624678

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

624679

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

624685

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.479

High

173854

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

327161

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

417940

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

445729

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

461136

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.458

High

580594

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

624609

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.458

High

624633

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

624650

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

624662

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

624674

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

624681

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

624683

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

624686

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.458

High

624626

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.457

High

166252

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

563169

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

624602

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.445

High

624625

1433Z
14-3-3 protein zeta/delta

1

8

Small-scale

0.445

High

624630

ACVR1
Activin receptor type-1

1

2

High-throughput

0.445

High

624647

STX12
Syntaxin-12

1

3

High-throughput

0.445

High

624649

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.445

High

624656

MOT10
Monocarboxylate transporter 10

1

2

High-throughput

0.445

High

624664

S1PR3
Sphingosine 1-phosphate receptor 3

1

4

High-throughput

0.445

High

105306

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

624680

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

0

High-throughput

0.426

High

624652

XXLT1
Xyloside xylosyltransferase 1

1

1

High-throughput

0.407

High

624646

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

624670

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

624668

S35A5
UDP-sugar transporter protein SLC35A5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025