HitPredict

Interactor 1: RBM11 (P57052)
Splicing regulator RBM11 (RNA-binding motif protein 11)
Gene: RBM11

Interactor 2: SF3B2 (Q13435)
Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)
Gene: SF3B2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.864

Property	Details
Experiments	26186194, 33961781, 35914814
Identification Methods	affinity chromatography technology, two hybrid, two hybrid fragment pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PSP~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 895
+	Hs
		1034443 RBM7_HUMAN (1-267): 7.89e-34: 125: 31.85		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Hs
		1034292 SF3B4_HUMAN (9-111): 3.63e-21: 94: 26.67		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Hs
		1034434 PPIE_HUMAN (10-90): 1.92e-12: 67.8: 32.96		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Hs
		92678 SF3B4_HUMAN (9-111): 3.63e-21: 94: 26.67		E9PPJ0_HUMAN (1-895): 0: 1094: 98.10
+	Dm
		1372645 Q9W424_DROME (9-135): 2.05e-24: 102: 26.15		Q9VQK7_DROME (278-895): 0: 687: 57.90
+	Pf
		1212910 Q8ILQ0_PLAF7 (5-91): 3.43e-18: 85.9: 32.96		Q8IKL7_PLAF7 (351-728): 2.06e-122: 387: 38.16
+	Sc
		971709 HSH49_YEAST (5-112): 1.04e-29: 113: 30.63		CUS1_YEAST (326-754): 2.32e-111: 350: 26.77
+	Sc
		376903 PABP_YEAST (6-99): 1.95e-18: 86.8: 23.16		CUS1_YEAST (326-754): 2.32e-111: 350: 26.77