Protein: RSC4
Chromatin structure-remodeling complex subunit RSC4 (RSC complex subunit RSC4) (Remodel the structure of chromatin complex subunit 4)

Gene: RSC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 169
UniProt ID: Q02206

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0006337 - nucleosome disassembly
GO:0006338 - chromatin remodeling
GO:0006368 - transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1035336

RSC2
Chromatin structure-remodeling complex subunit RSC2

16

19

Small-scale

0.981

High

743123

STH1
Nuclear protein STH1/NPS1

12

20

Small-scale

0.976

High

1035341

RSC58
Chromatin structure-remodeling complex protein RSC58

8

5

Small-scale

0.966

High

918519

RSC1
Chromatin structure-remodeling complex subunit RSC1

7

19

Small-scale

0.954

High

1035313

RSC4
Chromatin structure-remodeling complex subunit RSC4

4

17

Small-scale

0.868

High

1035319

GCN5
Histone acetyltransferase GCN5

3

20

Small-scale

0.818

High

823021

ATAD2
ATPase histone chaperone YTA7

3

14

High-throughput

0.817

High

850558

RSC8
Chromatin structure-remodeling complex protein RSC8

7

20

Small-scale

0.745

High

745606

RSC7
Chromatin structure-remodeling complex subunit RSC7

7

5

Small-scale

0.744

High

1035318

RSC9
Chromatin structure-remodeling complex subunit RSC9

7

4

Small-scale

0.744

High

1035332

SFH1
Chromatin structure-remodeling complex subunit SFH1

7

15

Small-scale

0.744

High

777100

BDF1
Bromodomain-containing factor 1

2

18

High-throughput

0.737

High

678335

RSC6
Chromatin structure-remodeling complex protein RSC6

6

20

High-throughput

0.732

High

1035328

ARP9
Actin-like protein ARP9

6

20

High-throughput

0.730

High

1035338

RSC3
Chromatin structure-remodeling complex protein RSC3

6

8

High-throughput

0.730

High

1035355

ARP7
Actin-related protein 7

6

20

High-throughput

0.730

High

919682

RT102
Regulator of Ty1 transposition protein 102

5

4

High-throughput

0.714

High

1035363

HTL1
High temperature lethal protein 1

4

3

High-throughput

0.673

High

794205

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

3

20

High-throughput

0.657

High

739731

SPT16
FACT complex subunit SPT16

3

8

High-throughput

0.640

High

752631

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.618

High

382291

H4
Histone H4

4

20

Small-scale

0.617

High

963658

H3
Histone H3

3

20

Small-scale

0.599

High

736705

ASF1
Histone chaperone ASF1

1

10

High-throughput

0.575

High

561512

TBP
TATA-box-binding protein

2

13

High-throughput

0.571

High

796032

LDB7
Chromatin structure-remodeling complex protein RSC14

2

3

High-throughput

0.571

High

803999

RSC30
Chromatin structure-remodeling complex protein RSC30

2

8

High-throughput

0.571

High

1035348

SCC1
Sister chromatid cohesion protein 1

2

5

High-throughput

0.571

High

1035361

H2AZ
Histone H2A.Z

2

20

High-throughput

0.571

High

826759

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

632205

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

Small-scale

0.527

High

381217

H2B1
Histone H2B.1

2

20

High-throughput

0.521

High

381603

H2B2
Histone H2B.2

2

20

High-throughput

0.521

High

419841

H2A2
Histone H2A.2

2

20

High-throughput

0.521

High

734460

BTAF1
TATA-binding protein-associated factor MOT1

2

20

Small-scale

0.521

High

763976

SPT10
Protein SPT10

2

4

High-throughput

0.521

High

924994

APJ1
J domain-containing protein APJ1

2

14

High-throughput

0.521

High

819553

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.504

High

830248

ARF3
ADP-ribosylation factor 3

1

1

High-throughput

0.494

High

524886

HSP71
Heat shock protein SSA1

1

16

High-throughput

0.489

High

545951

SSB1
Ribosome-associated molecular chaperone SSB1

1

18

High-throughput

0.489

High

402094

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

15

Small-scale

0.479

High

594524

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

7

High-throughput

0.479

High

795158

NU170
Nucleoporin NUP170

1

2

High-throughput

0.479

High

757519

NCBP1
Nuclear cap-binding protein complex subunit 1

1

2

High-throughput

0.470

High

444869

SIR3
Regulatory protein SIR3

1

6

High-throughput

0.445

High

547821

NHP6A
Non-histone chromosomal protein 6A

1

20

High-throughput

0.445

High

548792

MCM1
Pheromone receptor transcription factor

1

5

High-throughput

0.445

High

650006

SIN3
Transcriptional regulatory protein SIN3

1

8

High-throughput

0.445

High

661189

SPT6
Transcription elongation factor SPT6

1

9

High-throughput

0.445

High

664464

MCM3
DNA replication licensing factor MCM3

1

15

High-throughput

0.445

High

671549

SWI4
Regulatory protein SWI4

1

14

High-throughput

0.445

High

694623

SPT5
Transcription elongation factor SPT5

1

8

High-throughput

0.445

High

713026

MCM2
DNA replication licensing factor MCM2

1

15

High-throughput

0.445

High

713295

MCM5
Minichromosome maintenance protein 5

1

15

High-throughput

0.445

High

737684

HIR2
Protein HIR2

1

20

High-throughput

0.445

High

739904

RPD3
Histone deacetylase RPD3

1

20

High-throughput

0.445

High

744330

CHD1
Chromo domain-containing protein 1

1

20

High-throughput

0.445

High

757344

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.445

High

757772

SAS3
Histone acetyltransferase SAS3

1

19

High-throughput

0.445

High

793974

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

20

High-throughput

0.445

High

826167

SCC3
Cohesin subunit SCC3

1

1

High-throughput

0.445

High

858456

TAF1
Transcription initiation factor TFIID subunit 1

1

13

High-throughput

0.445

High

916589

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

12

High-throughput

0.445

High

917310

INO80
Chromatin-remodeling ATPase INO80

1

20

High-throughput

0.445

High

917398

ITC1
Imitation switch two complex protein 1

1

8

High-throughput

0.445

High

921156

H1
Histone H1

1

2

High-throughput

0.445

High

948629

ACT
Actin

1

20

High-throughput

0.445

High

1010199

ARP4
Actin-related protein 4

1

20

High-throughput

0.445

High

1035314

ADA2
SAGA complex subunit ADA2

1

20

High-throughput

0.445

High

1035320

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

13

High-throughput

0.445

High

1035321

RUVB1
RuvB-like protein 1

1

11

High-throughput

0.445

High

1035322

IOC4
ISWI one complex protein 4

1

1

High-throughput

0.445

High

1035323

TAF11
Transcription initiation factor TFIID subunit 11

1

4

High-throughput

0.445

High

1035324

PDS5
Sister chromatid cohesion protein PDS5

1

3

High-throughput

0.445

High

1035325

DPB4
DNA polymerase epsilon subunit D

1

8

High-throughput

0.445

High

1035326

POB3
FACT complex subunit POB3

1

12

High-throughput

0.445

High

1035327

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

11

High-throughput

0.445

High

1035329

SWR1
Helicase SWR1

1

20

High-throughput

0.445

High

1035333

PDP3
NuA3 HAT complex component PDP3

1

10

High-throughput

0.445

High

1035334

EAF1
Chromatin modification-related protein EAF1

1

1

High-throughput

0.445

High

1035337

IWS1
Transcription factor SPN1

1

2

High-throughput

0.445

High

1035344

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

20

High-throughput

0.445

High

1035346

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

11

High-throughput

0.445

High

1035347

IOC2
ISWI one complex protein 2

1

1

High-throughput

0.445

High

1035350

TAF3
Transcription initiation factor TFIID subunit 3

1

1

High-throughput

0.445

High

1035351

NTO1
NuA3 HAT complex component NTO1

1

20

High-throughput

0.445

High

1035354

ARP8
Actin-like protein ARP8

1

20

High-throughput

0.445

High

1035357

EAF3
Chromatin modification-related protein EAF3

1

3

High-throughput

0.445

High

1035358

AHC1
Protein AHC1

1

1

High-throughput

0.445

High

1035359

RUVB2
RuvB-like protein 2

1

11

High-throughput

0.445

High

1035360

CAF1A
Chromatin assembly factor 1 subunit A

1

10

High-throughput

0.445

High

1035362

NCB2
Negative cofactor 2 complex subunit beta

1

8

High-throughput

0.445

High

448997

TOP2
DNA topoisomerase 2

1

15

High-throughput

0.437

High

617984

IRA1
Inhibitory regulator protein IRA1

1

7

High-throughput

0.437

High

646505

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.437

High

647189

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.437

High

647823

RFA1
Replication factor A protein 1

1

7

Small-scale

0.437

High

680610

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

3

High-throughput

0.437

High

707942

TF2B
Transcription initiation factor IIB

1

14

High-throughput

0.437

High

735121

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

5

High-throughput

0.437

High

741068

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

9

High-throughput

0.437

High

745531

MRE11
Double-strand break repair protein MRE11

1

5

Small-scale

0.437

High

745846

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

8

High-throughput

0.437

High

748006

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

815659

LIS1
Nuclear distribution protein PAC1

1

14

High-throughput

0.437

High

923917

SYC
Cysteine--tRNA ligase

1

1

High-throughput

0.437

High

1035330

HRQ1
ATP-dependent helicase HRQ1

1

18

High-throughput

0.437

High

1035342

MED7
Mediator of RNA polymerase II transcription subunit 7

1

2

Small-scale

0.437

High

1035343

SGO1
Shugoshin

1

2

High-throughput

0.437

High

817707

IES5
Ino eighty subunit 5

1

0

High-throughput

0.426

High

820436

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

850378

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.426

High

932315

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.426

High

1035315

TBF1
Protein TBF1

1

0

High-throughput

0.426

High

1035353

IES3
Ino eighty subunit 3

1

0

High-throughput

0.426

High

393198

HSP82
ATP-dependent molecular chaperone HSP82

1

14

High-throughput

0.407

High

394833

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.407

High

445363

CDC31
Cell division control protein 31

1

2

High-throughput

0.407

High

448211

HAP2
Transcriptional activator HAP2

1

4

High-throughput

0.407

High

488990

SWI6
Regulatory protein SWI6

1

16

High-throughput

0.407

High

510743

HSP77
Import motor subunit, mitochondrial

1

17

High-throughput

0.407

High

527464

HSP72
Heat shock protein SSA2

1

16

High-throughput

0.407

High

550074

RAP1
DNA-binding protein RAP1

1

2

High-throughput

0.407

High

577200

SEC63
Protein translocation protein SEC63

1

11

High-throughput

0.407

High

579921

HSC82
ATP-dependent molecular chaperone HSC82

1

14

High-throughput

0.407

High

676276

MAS5
Mitochondrial protein import protein MAS5

1

14

High-throughput

0.407

High

676669

SGF29
SAGA complex subunit SGF29

1

2

High-throughput

0.407

High

708775

TF3B
Transcription factor IIIB 70 kDa subunit

1

14

High-throughput

0.407

High

742209

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.407

High

743272

PP12
Serine/threonine-protein phosphatase PP1-2

1

12

High-throughput

0.407

High

751904

TFC4
Transcription factor tau 131 kDa subunit

1

11

High-throughput

0.407

High

753035

SPC29
Spindle pole component 29

1

1

High-throughput

0.407

High

779322

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.407

High

781785

SET3
SET domain-containing protein 3

1

20

High-throughput

0.407

High

782092

RL1D1
Ribosome biogenesis protein UTP30

1

3

High-throughput

0.407

High

805208

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

16

High-throughput

0.407

High

811019

TCPD
T-complex protein 1 subunit delta

1

9

High-throughput

0.407

High

836852

MPG1
Mannose-1-phosphate guanyltransferase

1

4

High-throughput

0.407

High

849866

GAT1
Transcriptional regulatory protein GAT1

1

20

High-throughput

0.407

High

858416

SUM1
Suppressor of mar1-1 protein

1

1

High-throughput

0.407

High

858495

TFC5
Transcription factor TFIIIB component B''

1

1

High-throughput

0.407

High

864314

NET1
Nucleolar protein NET1

1

1

High-throughput

0.407

High

865044

TCPQ
T-complex protein 1 subunit theta

1

8

High-throughput

0.407

High

871552

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

893327

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

20

High-throughput

0.407

High

917053

MCM6
DNA replication licensing factor MCM6

1

16

High-throughput

0.407

High

924046

JJJ1
J protein JJJ1

1

15

High-throughput

0.407

High

932324

ORC4
Origin recognition complex subunit 4

1

2

High-throughput

0.407

High

1026804

CDC14
Tyrosine-protein phosphatase CDC14

1

6

High-throughput

0.407

High

1035316

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

1

High-throughput

0.407

High

1035317

HOS3
Histone deacetylase HOS3

1

20

High-throughput

0.407

High

1035345

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

1

High-throughput

0.407

High

1035352

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High

1035339

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.279

Low

659162

MBR1
Mitochondrial biogenesis regulation protein 1

1

0

High-throughput

0.249

Low

736821

PHA2
Probable prephenate dehydratase

1

0

High-throughput

0.249

Low

805836

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.249

Low

813425

PO152
Nucleoporin POM152

1

0

High-throughput

0.249

Low

1035335

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

150077

COQ4
Ubiquinone biosynthesis protein COQ4, mitochondrial

1

0

High-throughput

0.232

Low

397497

REP1
Partitioning protein REP1

1

0

High-throughput

0.232

Low

898173

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.232

Low

912432

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low

1035331

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.232

Low

1035340

RAF
Trans-acting factor D

1

0

High-throughput

0.232

Low

1035349

RFM1
Repression factor of MSEs protein 1

1

0

High-throughput

0.232

Low

1035356

TFC7
Transcription factor tau 55 kDa subunit

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025