HitPredict

Interactor 1: SIK1 (P57059)
Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)
Gene: SIK1

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	32707033, 36806887, 16306228, 36931259
Identification Methods	affinity chromatography technology, tandem affinity purification, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007346 - regulation of mitotic cell cycle GO:0035556 - intracellular signal transduction GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 783 Hs			1 255
+	Hs
		910013 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Xl
		223345 Q8QGV3_XENLA (11-719): 4.86e-156: 475: 29.40		O57468_XENLA (1-255): 1.7e-152: 426: 96.47
+	Hs
		909730 MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910234 MARK2_MOUSE (5-716): 2.02e-153: 468: 29.53		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Mm
		910231 MARK3_MOUSE (18-634): 2.81e-152: 464: 32.08		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		647862 MARK3_HUMAN (18-634): 1.04e-151: 463: 31.60		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910318 MARK1_MOUSE (15-704): 3.85e-148: 455: 29.35		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		910106 MARK1_HUMAN (15-704): 7.62e-148: 454: 29.21		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		910187 SIK3_HUMAN (11-760): 1.44e-142: 454: 30.33		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		910071 SNRK_HUMAN (25-438): 9.94e-148: 453: 36.94		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Xl
		223344 Q804T2_XENLA (18-610): 1.38e-149: 456: 33.22		O57468_XENLA (1-255): 1.7e-152: 426: 96.47
+	Mm
		910308 MARK4_MOUSE (18-715): 4.24e-146: 448: 32.82		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		909916 MARK4_HUMAN (18-715): 3.07e-145: 446: 32.40		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909507 AAPK1_HUMAN (1-530): 1.08e-142: 433: 30.97		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		871354 AAPK2_HUMAN (13-523): 1.66e-142: 432: 31.41		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Rn
		871214 AAPK1_RAT (1-530): 1.02e-141: 430: 30.78		1433E_RAT (1-255): 4.87e-154: 430: 100.00
+	Dm
		90534 E1JGN0_DROME (7-676): 1.51e-141: 447: 29.40		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	At
		788672 CIPKC_ARATH (4-376): 1.84e-139: 422: 29.87		14333_ARATH (1-253): 3.45e-147: 413: 74.12
+	Sc
		419854 SNF1_YEAST (23-461): 5.7e-142: 433: 32.75		BMH2_YEAST (4-242): 1.14e-134: 382: 77.08
+	Sc
		419824 SNF1_YEAST (23-461): 5.7e-142: 433: 32.75		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72