Protein: CSK22
Casein kinase II subunit alpha' (CK II) (EC 2.7.11.1)

Gene: CSK22, CKA2
Organism: Saccharomyces cerevisiae S288C
Interactions: 221
UniProt ID: P19454

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622950

CSK2C
Casein kinase II subunit beta'

16

17

Small-scale

0.985

High

622974

CSK2B
Casein kinase II subunit beta

15

17

Small-scale

0.985

High

585848

CSK21
Casein kinase II subunit alpha

12

18

Small-scale

0.980

High

622867

CSK22
Casein kinase II subunit alpha'

3

18

High-throughput

0.857

High

622898

HOG1
Mitogen-activated protein kinase HOG1

3

19

Small-scale

0.855

High

622999

CDC14
Tyrosine-protein phosphatase CDC14

3

11

Small-scale

0.847

High

622875

MPIP
M-phase inducer phosphatase

2

12

Small-scale

0.799

High

622949

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

11

Small-scale

0.755

High

622904

CHD1
Chromo domain-containing protein 1

7

13

Small-scale

0.749

High

622877

SIS1
Protein SIS1

2

6

High-throughput

0.737

High

622919

SPT23
Protein SPT23

1

12

Small-scale

0.724

High

623018

FKBP4
FK506-binding protein 4

2

12

High-throughput

0.712

High

381860

H4
Histone H4

5

5

Small-scale

0.704

High

622985

UTP22
U3 small nucleolar RNA-associated protein 22

4

1

High-throughput

0.694

High

560647

KIN2
Serine/threonine-protein kinase KIN2

1

7

High-throughput

0.691

High

622891

HRR25
Casein kinase I homolog HRR25

1

8

High-throughput

0.691

High

622906

SWE1
Mitosis inhibitor protein kinase SWE1

1

20

High-throughput

0.691

High

622932

AKL1
Serine/threonine-protein kinase AKL1

1

12

High-throughput

0.691

High

622953

SAK1
SNF1-activating kinase 1

1

13

High-throughput

0.691

High

622965

FKH1
Fork head protein homolog 1

1

4

High-throughput

0.691

High

623000

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

20

High-throughput

0.691

High

623007

PKH1
Serine/threonine-protein kinase PKH1

1

20

High-throughput

0.691

High

623029

HRK1
Serine/threonine-protein kinase HRK1

1

19

High-throughput

0.691

High

623033

RTK1
Probable serine/threonine-protein kinase RTK1

1

19

High-throughput

0.691

High

623005

HOT1
High-osmolarity-induced transcription protein 1

4

1

Small-scale

0.691

High

622955

IFH1
Protein IFH1

4

11

Small-scale

0.690

High

622901

SPT16
FACT complex subunit SPT16

10

5

Small-scale

0.689

High

622975

FIP1
Pre-mRNA polyadenylation factor FIP1

4

4

Small-scale

0.688

High

622994

H3
Histone H3

4

9

Small-scale

0.683

High

622874

SPT6
Transcription elongation factor SPT6

3

8

Small-scale

0.678

High

623038

RIO1
Serine/threonine-protein kinase RIO1

3

6

Small-scale

0.674

High

622927

ELF1
Transcription elongation factor 1

3

1

Small-scale

0.671

High

623015

SVF1
Ceramide-binding protein SVF1

3

1

Small-scale

0.670

High

622986

PESC
Pescadillo homolog

3

3

High-throughput

0.667

High

623037

PSH1
RING finger protein PSH1

3

6

Small-scale

0.664

High

623010

POB3
FACT complex subunit POB3

6

4

Small-scale

0.661

High

622996

RHO3
GTP-binding protein RHO3

1

4

High-throughput

0.656

High

622928

CAB3
Coenzyme A biosynthesis protein 3

5

4

High-throughput

0.651

High

622925

SIS2
Phosphopantothenoylcysteine decarboxylase subunit SIS2

3

4

High-throughput

0.647

High

438185

CDC37
Hsp90 co-chaperone Cdc37

1

6

Small-scale

0.647

High

622911

MSN2
Zinc finger protein MSN2

1

13

Small-scale

0.647

High

622912

MSN4
Zinc finger protein MSN4

1

14

Small-scale

0.647

High

419586

H2A2
Histone H2A.2

3

10

High-throughput

0.643

High

622922

BDF1
Bromodomain-containing factor 1

3

20

Small-scale

0.640

High

449394

SPT2
Protein SPT2

2

1

Small-scale

0.639

High

622968

SA185
SIT4-associating protein SAP185

2

8

High-throughput

0.628

High

622918

CENPC
Inner kinetochore subunit MIF2

2

1

Small-scale

0.625

High

622872

SIN3
Transcriptional regulatory protein SIN3

2

3

High-throughput

0.621

High

622995

CTR9
RNA polymerase-associated protein CTR9

2

13

High-throughput

0.621

High

623022

CDC73
Cell division control protein 73

2

1

High-throughput

0.621

High

622958

BEM2
GTPase-activating protein BEM2/IPL2

1

17

High-throughput

0.618

High

436313

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

9

High-throughput

0.618

High

488915

SWI6
Regulatory protein SWI6

1

13

High-throughput

0.618

High

622900

ZUO1
Zuotin

1

4

High-throughput

0.618

High

622940

RCK2
Serine/threonine-protein kinase RCK2

1

20

High-throughput

0.618

High

622954

YCFI
Metal resistance protein YCF1

1

3

Small-scale

0.618

High

444737

SIR2
NAD-dependent histone deacetylase SIR2

2

11

Small-scale

0.611

High

448920

TOP2
DNA topoisomerase 2

2

4

High-throughput

0.611

High

383080

RLA4
Large ribosomal subunit protein P2B

2

2

Small-scale

0.602

High

534044

HSF
Heat shock transcription factor

2

8

Small-scale

0.602

High

523009

HSP71
Heat shock protein SSA1

2

14

High-throughput

0.601

High

543765

SSB1
Ribosome-associated molecular chaperone SSB1

2

14

High-throughput

0.601

High

622903

PP12
Serine/threonine-protein phosphatase PP1-2

2

15

High-throughput

0.601

High

622960

SSB2
Ribosome-associated molecular chaperone SSB2

2

14

High-throughput

0.601

High

623003

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.590

High

622897

ASF1
Histone chaperone ASF1

2

1

High-throughput

0.588

High

622966

ULP2
Ubiquitin-like-specific protease 2

2

3

High-throughput

0.586

High

622967

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

577030

SEC63
Protein translocation protein SEC63

1

5

Small-scale

0.579

High

622969

MAF1
Repressor of RNA polymerase III transcription MAF1

1

3

Small-scale

0.578

High

623024

PSR1
Phosphatase PSR1

2

5

Small-scale

0.576

High

622983

XRCC4
Non-homologous end-joining factor LIF1

2

0

Small-scale

0.576

High

392199

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.575

High

622881

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.575

High

380957

H2B1
Histone H2B.1

2

9

High-throughput

0.571

High

622888

SPT5
Transcription elongation factor SPT5

2

7

High-throughput

0.571

High

622896

SFP1
Transcription factor SFP1

2

1

Small-scale

0.571

High

622947

YHT1
PH domain-containing protein YHR131C

2

1

High-throughput

0.571

High

622962

ATAD2
ATPase histone chaperone YTA7

2

9

Small-scale

0.571

High

561413

TBP
TATA-box-binding protein

1

1

Small-scale

0.561

High

570786

ABF1
ARS-binding factor 1

1

1

Small-scale

0.561

High

622870

CLH
Clathrin heavy chain

1

4

Small-scale

0.561

High

623032

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.561

High

438379

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

11

Small-scale

0.553

High

449062

CALM
Calmodulin

1

20

Small-scale

0.553

High

622936

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

20

Small-scale

0.549

High

622923

DHR2
Probable ATP-dependent RNA helicase DHR2

1

7

High-throughput

0.541

High

622988

NOP19
Nucleolar protein 19

1

1

High-throughput

0.541

High

622952

SEC31
Protein transport protein SEC31

2

17

High-throughput

0.537

High

534209

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

10

High-throughput

0.536

High

535976

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

4

High-throughput

0.536

High

622892

XPO1
Exportin-1

1

9

High-throughput

0.536

High

622915

SPT7
SAGA complex subunit SPT7

1

20

High-throughput

0.536

High

622916

RRP1
Ribosomal RNA-processing protein 1

1

5

High-throughput

0.536

High

622933

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

17

High-throughput

0.536

High

622937

TTL
Probable tubulin--tyrosine ligase PBY1

1

4

High-throughput

0.536

High

622945

CIC1
Proteasome-interacting protein CIC1

1

2

High-throughput

0.536

High

622961

RIO2
Serine/threonine-protein kinase RIO2

1

6

High-throughput

0.536

High

622963

UTP18
U3 small nucleolar RNA-associated protein 18

1

2

High-throughput

0.536

High

622977

NET1
Nucleolar protein NET1

1

3

High-throughput

0.536

High

622982

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

7

High-throughput

0.536

High

622989

PXR1
Protein PXR1

1

1

High-throughput

0.536

High

623002

TOF2
Topoisomerase 1-associated factor 2

1

3

High-throughput

0.536

High

623006

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.536

High

623011

ERB1
Ribosome biogenesis protein ERB1

1

17

High-throughput

0.536

High

623019

ESF1
Pre-rRNA-processing protein ESF1

1

2

High-throughput

0.536

High

623025

PSR2
Probable phosphatase PSR2

1

5

High-throughput

0.536

High

623031

CTI6
Histone deacetylase complex subunit CTI6

1

5

High-throughput

0.536

High

623040

RRP36
rRNA biogenesis protein RRP36

1

1

Small-scale

0.536

High

622914

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.518

High

622938

PAF1
RNA polymerase II-associated protein 1

1

2

High-throughput

0.515

High

622991

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

5

High-throughput

0.515

High

622878

SCJ1
DnaJ-related protein SCJ1

1

5

High-throughput

0.514

High

622978

HLJ1
Protein HLJ1

1

4

High-throughput

0.514

High

622884

CSM1
Monopolin complex subunit CSM1

1

0

High-throughput

0.513

High

622913

MKS1
Negative regulator of RAS-cAMP pathway

1

0

High-throughput

0.513

High

623030

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.513

High

622908

SLA2
Protein SLA2

1

20

Small-scale

0.512

High

622981

TOM22
Mitochondrial import receptor subunit TOM22

1

1

Small-scale

0.512

High

454393

PHO4
Phosphate system positive regulatory protein PHO4

1

1

Small-scale

0.501

High

574768

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

10

Small-scale

0.501

High

622869

OPI1
Transcriptional repressor OPI1

1

1

Small-scale

0.501

High

622889

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

10

High-throughput

0.501

High

622899

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

1

Small-scale

0.501

High

622902

PAH1
Phosphatidic acid phosphohydrolase 1

1

4

Small-scale

0.501

High

622939

IF5
Eukaryotic translation initiation factor 5

1

8

Small-scale

0.501

High

622941

SIC1
Protein SIC1

1

1

Small-scale

0.501

High

623004

NRG1
Transcriptional regulator NRG1

1

11

Small-scale

0.501

High

623009

PUF6
Pumilio homology domain family member 6

1

6

Small-scale

0.501

High

623012

CRF1
Transcription factor CRF1

1

2

Small-scale

0.501

High

367687

ENO1
Enolase 1

1

4

High-throughput

0.500

High

405021

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.500

High

578210

TAL1
Transaldolase

1

2

High-throughput

0.500

High

622957

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.500

High

582408

SEC23
Protein transport protein SEC23

1

1

High-throughput

0.489

High

622907

DOM34
Protein DOM34

1

1

High-throughput

0.489

High

623027

VHS3
Phosphopantothenoylcysteine decarboxylase subunit VHS3

1

5

High-throughput

0.489

High

572511

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.479

High

622893

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.479

High

149571

RS9A
Small ribosomal subunit protein uS4A

1

5

High-throughput

0.479

High

381390

H2B2
Histone H2B.2

1

9

High-throughput

0.479

High

383506

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

419352

H2A1
Histone H2A.1

1

10

High-throughput

0.479

High

434805

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

454861

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.479

High

512804

RS8A
Small ribosomal subunit protein eS8A

1

4

High-throughput

0.479

High

514444

RS18A
Small ribosomal subunit protein uS13A

1

5

High-throughput

0.479

High

548814

TAF13
Transcription initiation factor TFIID subunit 13

1

1

Small-scale

0.479

High

622871

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

5

High-throughput

0.479

High

622876

NAP1
Nucleosome assembly protein

1

20

Small-scale

0.479

High

622879

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

622880

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

622882

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

622885

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

622887

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

622890

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

622894

FUN30
ATP-dependent helicase FUN30

1

15

High-throughput

0.479

High

622895

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

622910

RS3A1
Small ribosomal subunit protein eS1A

1

7

High-throughput

0.479

High

622924

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.479

High

622942

RS20
Small ribosomal subunit protein uS10

1

5

High-throughput

0.479

High

622956

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

622972

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

15

High-throughput

0.479

High

622980

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

622993

ORC1
Origin recognition complex subunit 1

1

11

High-throughput

0.479

High

623001

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

623008

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.479

High

623014

SWR1
Helicase SWR1

1

11

High-throughput

0.479

High

623017

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

623021

UTP4
U3 small nucleolar RNA-associated protein 4

1

12

Small-scale

0.479

High

623028

SGO1
Shugoshin

1

1

High-throughput

0.479

High

623035

SSF2
Ribosome biogenesis protein SSF2

1

3

High-throughput

0.479

High

623036

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

623039

DBP10
ATP-dependent RNA helicase DBP10

1

19

High-throughput

0.479

High

622883

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.458

High

622971

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

427132

RLA0
Large ribosomal subunit protein uL10

1

5

Small-scale

0.457

High

427538

RLA1
Large ribosomal subunit protein P1A

1

3

Small-scale

0.457

High

622917

TOM20
Mitochondrial import receptor subunit TOM20

1

1

Small-scale

0.457

High

622987

DAM1
DASH complex subunit DAM1

1

1

Small-scale

0.457

High

623026

MIM1
Mitochondrial import protein 1

1

1

Small-scale

0.457

High

622873

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.457

High

622886

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

15

High-throughput

0.457

High

622931

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

5

High-throughput

0.457

High

622944

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

2

High-throughput

0.457

High

525882

HSP72
Heat shock protein SSA2

1

14

High-throughput

0.445

High

622909

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

622929

SET3
SET domain-containing protein 3

1

10

High-throughput

0.445

High

622930

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.445

High

622948

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

2

High-throughput

0.445

High

622964

6P21
6-phosphofructo-2-kinase 1

1

4

High-throughput

0.445

High

622998

SEN1
Helicase SEN1

1

2

Small-scale

0.445

High

623020

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

16

High-throughput

0.445

High

623041

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.445

High

558573

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

622934

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

622946

NMD2
Nonsense-mediated mRNA decay protein 2

1

1

Small-scale

0.437

High

622951

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

Small-scale

0.437

High

622990

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

622992

NST1
Stress response protein NST1

1

19

High-throughput

0.437

High

622997

NUM1
Nuclear migration protein NUM1

1

20

High-throughput

0.437

High

623023

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

622926

MID2
Cell wall integrity sensor MID2

1

6

High-throughput

0.417

High

622984

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.417

High

623013

RTN1
Reticulon-like protein 1

1

4

High-throughput

0.417

High

622920

MNR2
Manganese resistance protein MNR2

1

1

High-throughput

0.407

High

622973

LSB3
LAS seventeen-binding protein 3

1

4

High-throughput

0.407

High

622976

STU2
Protein STU2

1

8

High-throughput

0.407

High

623016

YL407
Uncharacterized protein YLR407W

3

0

High-throughput

0.339

High

623034

ATG9
Autophagy-related protein 9

2

0

High-throughput

0.318

High

622979

ASK10
Activator of SKN7 protein 10

1

0

High-throughput

0.279

Low

456503

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

0

High-throughput

0.269

Low

622959

RSM18
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.269

Low

439084

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

622905

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

622868

HNM1
Choline transporter

1

0

High-throughput

0.238

Low

622921

SFK1
Protein SFK1

1

0

High-throughput

0.238

Low

622935

RFS1
Protein RFS1

1

0

High-throughput

0.238

Low

622943

LAG1
Ceramide synthase LAG1

1

0

High-throughput

0.238

Low

622970

MDJ2
Mitochondrial DnaJ homolog 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025