HitPredict

Interactor 1: UBS3A (P57075)
Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
Gene: UBASH3A

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	32296183, 31659016, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0050860 - negative regulation of T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 661 Hs			1 982
+	Mm
		1112052 UBS3A_MOUSE (1-661): 0: 984: 78.40		CBLB_MOUSE (1-982): 0: 873: 95.12
+	Hs
		1027618 UBS3B_HUMAN (1-655): 0: 904: 43.07		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Mm
		1112064 UBS3B_MOUSE (1-655): 0: 897: 42.77		CBLB_MOUSE (1-982): 0: 873: 95.12
+	Hs
		610317 UBS3A_HUMAN (1-661): 0: 1048: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610596 UBS3A_MOUSE (1-661): 0: 984: 78.40		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		610459 UBS3B_HUMAN (1-655): 0: 904: 43.07		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610620 UBS3B_MOUSE (1-655): 0: 897: 42.77		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		235501 VINEX_HUMAN (202-339): 5.67e-28: 121: 22.86		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		298976 SRBS2_HUMAN (200-339): 2.17e-23: 107: 22.37		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Mm
		1112057 SRBS1_MOUSE (234-339): 4.67e-22: 103: 24.53		CBLB_MOUSE (1-982): 0: 873: 95.12
+	Hs
		235473 VINEX_HUMAN (202-339): 5.67e-28: 121: 22.86		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		298949 SRBS2_HUMAN (200-339): 2.17e-23: 107: 22.37		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610595 SRBS2_MOUSE (200-339): 3.02e-23: 107: 21.05		CBL_MOUSE (25-976): 0: 674: 47.47
+	Mm
		610608 SRBS1_MOUSE (234-339): 4.67e-22: 103: 24.53		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		610501 SRBS1_HUMAN (145-339): 1.51e-20: 99.1: 21.46		CBL_HUMAN (25-976): 0: 675: 47.10
+	Ce
		104709 SRBS1_CAEEL (198-338): 3.3e-25: 113: 23.03		Q19019_CAEEL (41-555): 0: 640: 44.40
+	Hs
		203191 VINEX_HUMAN (202-339): 5.67e-28: 121: 22.86		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Hs
		203192 SRBS2_HUMAN (200-339): 2.17e-23: 107: 22.37		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Hs
		203250 SRBS1_HUMAN (145-339): 1.51e-20: 99.1: 21.46		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Rn
		192744 SRBS2_RAT (200-339): 1.15e-23: 108: 21.05		SYNJ1_RAT (687-978): 9.27e-09: 62: 10.51