Protein: UB2R2
Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)

Gene: UB2R2, UBE2R2
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q712K3

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

983858

RBX1
E3 ubiquitin-protein ligase RBX1

8

20

Small-scale

0.965

High

647586

UBA1
Ubiquitin-like modifier-activating enzyme 1

5

20

Small-scale

0.917

High

508183

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

20

Small-scale

0.914

High

1258832

FBW1A
F-box/WD repeat-containing protein 1A

4

20

Small-scale

0.899

High

1258830

FBW1B
F-box/WD repeat-containing protein 11

4

20

High-throughput

0.881

High

335144

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.698

High

1258770

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

1258784

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

16

High-throughput

0.698

High

1258831

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

High-throughput

0.698

High

1258768

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

15

Small-scale

0.692

High

883269

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

16

High-throughput

0.691

High

921936

COPA
Coatomer subunit alpha

1

3

High-throughput

0.691

High

242083

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

1028252

MDM2
E3 ubiquitin-protein ligase Mdm2

1

13

Small-scale

0.647

High

1258790

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

20

Small-scale

0.647

High

1258795

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

1258796

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.647

High

1028129

IRF9
Interferon regulatory factor 9

2

2

High-throughput

0.628

High

1258817

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

4

High-throughput

0.628

High

1258775

R113B
RING finger protein 113B

1

1

High-throughput

0.625

High

1258789

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.622

High

1258829

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

893704

MEOX1
Homeobox protein MOX-1

3

5

High-throughput

0.616

High

140322

SDCB1
Syntenin-1

2

3

High-throughput

0.606

High

987389

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

20

High-throughput

0.590

High

142358

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.575

High

773548

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.575

High

987085

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.575

High

1258800

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

2

1

High-throughput

0.574

High

192381

GSC2
Homeobox protein goosecoid-2

2

4

High-throughput

0.553

High

964023

COPZ1
Coatomer subunit zeta-1

1

1

High-throughput

0.536

High

1179176

CTC1
CST complex subunit CTC1

1

1

High-throughput

0.536

High

1258827

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.536

High

912580

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.508

High

764856

CTNB1
Catenin beta-1

1

4

Small-scale

0.501

High

1258769

MAEA
E3 ubiquitin-protein transferase MAEA

1

6

High-throughput

0.501

High

348871

CLIC3
Chloride intracellular channel protein 3

1

1

High-throughput

0.489

High

1258778

SYT2
Synaptotagmin-2

1

2

High-throughput

0.489

High

1258811

STN1
CST complex subunit STN1

1

1

High-throughput

0.489

High

1258793

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

0

High-throughput

0.486

High

567432

TCTP
Translationally-controlled tumor protein

1

5

High-throughput

0.479

High

942700

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

1177008

INF2
Inverted formin-2

1

1

High-throughput

0.464

High

1258812

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

Small-scale

0.458

High

48672

ESYT2
Extended synaptotagmin-2

1

5

High-throughput

0.445

High

213621

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

1

High-throughput

0.445

High

296517

STAM2
Signal transducing adapter molecule 2

1

6

High-throughput

0.445

High

360025

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.445

High

462482

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.445

High

535226

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.445

High

697931

CALR
Calreticulin

1

4

High-throughput

0.445

High

876909

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.445

High

883111

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

1

High-throughput

0.445

High

903972

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.445

High

921700

COPB
Coatomer subunit beta

1

1

High-throughput

0.445

High

952220

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.445

High

992227

SKP1
S-phase kinase-associated protein 1

1

6

High-throughput

0.445

High

1096988

PRDX4
Peroxiredoxin-4

1

1

High-throughput

0.445

High

1258773

DND1
Dead end protein homolog 1

1

2

High-throughput

0.445

High

1258774

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

3

High-throughput

0.445

High

1258779

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.445

High

1258781

VP37A
Vacuolar protein sorting-associated protein 37A

1

1

High-throughput

0.445

High

1258786

SCFD1
Sec1 family domain-containing protein 1

1

2

High-throughput

0.445

High

1258797

SCYL1
N-terminal kinase-like protein

1

3

High-throughput

0.445

High

1258820

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

1258825

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.445

High

1258837

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

1258813

SP110
Sp110 nuclear body protein

1

8

High-throughput

0.437

High

1258818

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

Small-scale

0.437

High

60361

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

125511

LEG9
Galectin-9

1

0

High-throughput

0.426

High

158243

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.426

High

211806

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

369186

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

873252

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

1009851

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

1139212

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

1139331

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

1248615

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

1258772

YAF2
YY1-associated factor 2

1

0

High-throughput

0.426

High

1258794

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

1258801

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1258806

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

1258808

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.426

High

1258809

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

1258816

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

1258836

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

104347

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.407

High

275530

RTN2
Reticulon-2

1

2

High-throughput

0.407

High

318995

MICA2
[F-actin]-monooxygenase MICAL2

1

2

High-throughput

0.407

High

328941

RTN3
Reticulon-3

1

2

High-throughput

0.407

High

330214

VENTX
Homeobox protein VENTX

1

6

High-throughput

0.407

High

333067

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.407

High

430065

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

584111

FOSL2
Fos-related antigen 2

1

2

High-throughput

0.407

High

698803

CALX
Calnexin

1

4

High-throughput

0.407

High

888908

TMEDA
Transmembrane emp24 domain-containing protein 10

1

4

High-throughput

0.407

High

903720

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.407

High

1015051

ARF5
ADP-ribosylation factor 5

1

4

High-throughput

0.407

High

1131294

GANAB
Neutral alpha-glucosidase AB

1

2

High-throughput

0.407

High

1146567

TMED2
Transmembrane emp24 domain-containing protein 2

1

3

High-throughput

0.407

High

1147780

DHC24
Delta(24)-sterol reductase

1

1

High-throughput

0.407

High

1152807

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

2

High-throughput

0.407

High

1199197

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.407

High

1258771

TF2LY
Homeobox protein TGIF2LY

1

1

High-throughput

0.407

High

1258777

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.407

High

1258782

ATLA2
Atlastin-2

1

2

High-throughput

0.407

High

1258785

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

5

High-throughput

0.407

High

1258787

ATLA1
Atlastin-1

1

2

High-throughput

0.407

High

1258798

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

5

High-throughput

0.407

High

1258799

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.407

High

1258803

ERP44
Endoplasmic reticulum resident protein 44

1

1

High-throughput

0.407

High

1258804

ESYT1
Extended synaptotagmin-1

1

5

High-throughput

0.407

High

1258807

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.407

High

1258810

TMX1
Thioredoxin-related transmembrane protein 1

1

2

High-throughput

0.407

High

1258815

RTN4
Reticulon-4

1

2

High-throughput

0.407

High

1258819

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.407

High

1258823

PSD3
PH and SEC7 domain-containing protein 3

1

1

High-throughput

0.407

High

1258824

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.407

High

1258833

DHRS7
Dehydrogenase/reductase SDR family member 7

1

3

High-throughput

0.407

High

1258834

TMED5
Transmembrane emp24 domain-containing protein 5

1

3

High-throughput

0.407

High

1258788

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.299

High

1208219

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1258828

PGAP2
Acyltransferase PGAP2

1

0

High-throughput

0.279

Low

279401

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

1054731

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.249

Low

50600

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

215587

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.232

Low

283286

ERLN1
Erlin-1

1

0

High-throughput

0.232

Low

567014

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.232

Low

1027056

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.232

Low

1136244

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.232

Low

1145601

RCN1
Reticulocalbin-1

1

0

High-throughput

0.232

Low

1258776

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.232

Low

1258780

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.232

Low

1258783

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.232

Low

1258791

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.232

Low

1258792

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

1258802

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

1258805

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

1258814

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

1258821

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

1258822

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

1258826

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.232

Low

1258835

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025