HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21931591
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 604
+	Hs
		1036078 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		883506 RIPK4_HUMAN (1-832): 0: 726: 100.00		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		1036348 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		883482 RIPK4_HUMAN (1-832): 0: 726: 100.00		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		957782 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		201790 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		201791 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		1036246 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		1035698 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		1036381 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		1036265 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		201782 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		957806 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		957698 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		1038292 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		RFFL_HUMAN (254-604): 6.11e-54: 189: 15.88
+	Dm
		1097133 ANKHM_DROME (396-574): 1.03e-24: 113: 17.03		DIAP2_DROME (9-100): 4.66e-25: 110: 31.52
+	Hs
		1038299 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		MIB2_HUMAN (544-603): 2.9e-10: 65.3: 35.00