HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	26972000
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 832 Hs			1 245
+	Hs
		1261299 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		RN138_HUMAN (1-245): 6.92e-57: 183: 100.00
+	Hs
		129545 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF5_HUMAN (8-245): 3.76e-30: 119: 15.06
+	Hs
		883500 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF3_HUMAN (2-245): 1.23e-28: 115: 14.69
+	Hs
		883631 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF4_HUMAN (8-207): 1.85e-27: 111: 13.14
+	Hs
		1318726 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		TRIM4_HUMAN (10-142): 6.25e-29: 115: 13.33
+	Dm
		65569 A8JNM5_DROME (313-830): 8.03e-106: 361: 23.77		Q9W4V2_DROME (156-240): 1.5e-20: 88.5: 25.29
+	Dm
		1108401 Q3KN55_DROME (310-733): 2.49e-105: 341: 24.71		Q8IRV4_DROME (156-240): 1.85e-20: 88.1: 25.29
+	Hs
		1283421 TNKS2_HUMAN (490-831): 4.65e-82: 287: 25.71		RN166_HUMAN (5-244): 4.23e-40: 140: 29.58
+	Mm
		886050 RIPK2_MOUSE (31-276): 4.75e-55: 201: 44.49		TRAF6_MOUSE (12-227): 4.49e-33: 127: 15.77
+	Hs
		201839 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25
+	Hs
		129516 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF5_HUMAN (8-245): 3.76e-30: 119: 15.06
+	Hs
		201788 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF3_HUMAN (2-245): 1.23e-28: 115: 14.69
+	Hs
		201823 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF4_HUMAN (8-207): 1.85e-27: 111: 13.14
+	Hs
		1349593 KDIS_HUMAN (251-655): 7.94e-53: 202: 18.63		KCMF1_HUMAN (147-236): 1.38e-25: 105: 32.22
+	Hs
		1021448 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		RING2_HUMAN (2-188): 8.11e-29: 112: 18.72
+	Hs
		1377873 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25
+	Hs
		1038345 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25
+	Hs
		584951 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		RO52_HUMAN (6-157): 6.92e-32: 123: 17.11
+	Hs
		129559 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF5_HUMAN (8-245): 3.76e-30: 119: 15.06
+	Hs
		1024671 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF3_HUMAN (2-245): 1.23e-28: 115: 14.69