Protein: ECM29
Proteasome component ECM29 (Extracellular mutant protein 29)

Gene: ECM29
Organism: Saccharomyces cerevisiae S288C
Interactions: 209
UniProt ID: P38737

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0036503 - ERAD pathway
GO:0042030 - ATPase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

803143

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

7

10

Small-scale

0.742

High

661512

PSA2
Proteasome subunit alpha type-2

5

11

High-throughput

0.712

High

803181

RPN5
26S proteasome regulatory subunit RPN5

5

3

Small-scale

0.712

High

750649

PRS6A
26S proteasome regulatory subunit 6A

5

9

Small-scale

0.711

High

750938

PRS7
26S proteasome regulatory subunit 7 homolog

4

14

High-throughput

0.691

High

803126

RPN3
26S proteasome regulatory subunit RPN3

4

1

High-throughput

0.691

High

803174

RPN8
26S proteasome regulatory subunit RPN8

4

3

High-throughput

0.691

High

803183

RPN6
26S proteasome regulatory subunit RPN6

4

2

High-throughput

0.691

High

803144

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

8

Small-scale

0.687

High

803131

PSA4
Proteasome subunit alpha type-4

4

13

Small-scale

0.686

High

738303

RPN12
26S proteasome regulatory subunit RPN12

3

1

High-throughput

0.662

High

803114

RPN10
26S proteasome regulatory subunit RPN10

3

2

High-throughput

0.662

High

740156

RPN2
26S proteasome regulatory subunit RPN2

3

5

High-throughput

0.656

High

750837

PRS6B
26S proteasome regulatory subunit 6B homolog

3

6

High-throughput

0.656

High

800839

PSB1
Proteasome subunit beta type-1

3

16

High-throughput

0.656

High

803111

RPN1
26S proteasome regulatory subunit RPN1

3

5

High-throughput

0.656

High

803132

PRS4
26S proteasome regulatory subunit 4 homolog

3

7

High-throughput

0.656

High

803155

PRS10
26S proteasome subunit RPT4

3

13

High-throughput

0.656

High

803163

PRS8
26S proteasome regulatory subunit 8 homolog

3

9

High-throughput

0.656

High

803167

RPN9
26S proteasome regulatory subunit RPN9

3

1

High-throughput

0.656

High

803169

RPN7
26S proteasome regulatory subunit RPN7

3

3

High-throughput

0.656

High

743980

RAD23
UV excision repair protein RAD23

3

7

High-throughput

0.643

High

645166

PSB4
Proteasome subunit beta type-4

3

13

Small-scale

0.640

High

392681

HSP82
ATP-dependent molecular chaperone HSP82

3

9

High-throughput

0.633

High

726998

HS104
Heat shock protein 104

3

4

High-throughput

0.633

High

721255

PSB5
Proteasome subunit beta type-5

3

16

Small-scale

0.624

High

796073

IMB2
Importin subunit beta-2

2

12

High-throughput

0.621

High

544746

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.601

High

803121

RV167
Reduced viability upon starvation protein 167

2

1

High-throughput

0.601

High

449339

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

2

1

High-throughput

0.588

High

553609

ERF1
Eukaryotic peptide chain release factor subunit 1

2

1

High-throughput

0.588

High

150283

RPN13
26S proteasome regulatory subunit RPN13

2

0

High-throughput

0.585

High

435068

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.584

High

435942

RS13
Small ribosomal subunit protein uS15

2

3

High-throughput

0.584

High

579332

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

636572

PSA7
Probable proteasome subunit alpha type-7

2

13

High-throughput

0.584

High

636657

PSA1
Proteasome subunit alpha type-1

2

11

High-throughput

0.584

High

661404

PSA3
Proteasome subunit alpha type-3

2

13

High-throughput

0.584

High

662038

PSB6
Proteasome subunit beta type-6

2

16

High-throughput

0.584

High

735926

PSA5
Proteasome subunit alpha type-5

2

11

High-throughput

0.584

High

803130

PSA6
Proteasome subunit alpha type-6

2

12

High-throughput

0.584

High

741508

HSP7F
Heat shock protein homolog SSE1

2

16

High-throughput

0.571

High

803158

APJ1
J domain-containing protein APJ1

2

6

High-throughput

0.571

High

803142

BLM10
Proteasome activator BLM10

2

0

High-throughput

0.559

High

526606

HSP72
Heat shock protein SSA2

2

13

High-throughput

0.552

High

751695

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

2

4

High-throughput

0.537

High

803157

NAT10
RNA cytidine acetyltransferase

2

2

High-throughput

0.537

High

459087

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.536

High

757832

PP2C3
Protein phosphatase 2C homolog 3

1

4

High-throughput

0.536

High

802539

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.536

High

803172

RBX1
RING-box protein HRT1

1

6

High-throughput

0.536

High

803184

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.536

High

383683

RS17A
Small ribosomal subunit protein eS17A

2

2

High-throughput

0.533

High

455043

RS19A
Small ribosomal subunit protein eS19A

2

3

High-throughput

0.533

High

661622

MPCP
Mitochondrial phosphate carrier protein

1

9

High-throughput

0.489

High

779403

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.489

High

557703

SRS2
ATP-dependent DNA helicase SRS2

1

3

Small-scale

0.481

High

803134

PRK1
Actin-regulating kinase PRK1

1

0

Small-scale

0.480

High

358204

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.479

High

359212

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.479

High

365035

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.479

High

386699

TBB
Tubulin beta chain

1

7

High-throughput

0.479

High

394523

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.479

High

427261

RLA0
Large ribosomal subunit protein uL10

1

4

High-throughput

0.479

High

432565

RL7A
Large ribosomal subunit protein uL30A

1

4

High-throughput

0.479

High

433195

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.479

High

439327

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.479

High

450581

FAS1
Fatty acid synthase subunit beta

1

1

High-throughput

0.479

High

453580

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.479

High

458960

LYS2
L-2-aminoadipate reductase

1

2

High-throughput

0.479

High

477555

MYO1
Myosin-1

1

2

High-throughput

0.479

High

510459

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.479

High

512069

RS4A
Small ribosomal subunit protein eS4A

1

1

High-throughput

0.479

High

514621

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

518284

IF4A
ATP-dependent RNA helicase eIF4A

1

11

High-throughput

0.479

High

523834

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.479

High

531724

RL4A
Large ribosomal subunit protein uL4A

1

6

High-throughput

0.479

High

558706

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

570000

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

592229

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.479

High

594353

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

644921

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

3

High-throughput

0.479

High

647762

RFA1
Replication factor A protein 1

1

9

High-throughput

0.479

High

649490

UBA1
Ubiquitin-activating enzyme E1 1

1

1

High-throughput

0.479

High

668384

PSB2
Proteasome subunit beta type-2

1

12

High-throughput

0.479

High

674602

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

675244

PSB3
Proteasome subunit beta type-3

1

13

High-throughput

0.479

High

679643

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

684710

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

688878

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.479

High

707005

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

721304

PSB7
Proteasome subunit beta type-7

1

16

High-throughput

0.479

High

734961

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

739069

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

4

High-throughput

0.479

High

757695

EDE1
EH domain-containing and endocytosis protein 1

1

2

High-throughput

0.479

High

778310

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

792025

GBLP
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.479

High

796410

TRM7
tRNA

1

2

High-throughput

0.479

High

802149

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

803117

END3
Actin cytoskeleton-regulatory complex protein END3

1

3

High-throughput

0.479

High

803122

SNF7
Vacuolar-sorting protein SNF7

1

6

High-throughput

0.479

High

803138

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

803141

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.479

High

803151

RPN14
26S proteasome regulatory subunit RPN14

1

12

High-throughput

0.479

High

803152

CDH1
APC/C activator protein CDH1

1

14

Small-scale

0.479

High

803156

CAF40
Protein CAF40

1

1

High-throughput

0.479

High

803159

ACT
Actin

1

6

High-throughput

0.479

High

803160

H3
Histone H3

1

6

High-throughput

0.479

High

803162

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

803166

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.479

High

803173

MCA1
Metacaspase-1

1

1

High-throughput

0.479

High

803176

BMS1
Ribosome biogenesis protein BMS1

1

2

High-throughput

0.479

High

803179

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

1

9

High-throughput

0.479

High

803180

RIO1
Serine/threonine-protein kinase RIO1

1

6

High-throughput

0.479

High

314867

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.458

High

365614

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

366711

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

587305

ABP1
Actin-binding protein

1

0

High-throughput

0.458

High

603051

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

761109

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.458

High

779989

POC2
Proteasome assembly chaperone 2

1

0

High-throughput

0.458

High

797525

UMP1
Proteasome maturation factor UMP1

1

0

High-throughput

0.458

High

803113

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

803149

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

803170

VPS74
Vacuolar protein sorting-associated protein 74

1

0

High-throughput

0.458

High

803171

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.458

High

803177

RCN2
Regulator of calcineurin 2

1

0

High-throughput

0.458

High

803178

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

481609

HSP73
Heat shock protein SSA3

1

13

High-throughput

0.445

High

653855

HSP12
12 kDa heat shock protein

1

1

High-throughput

0.445

High

670671

SIS1
Protein SIS1

1

4

High-throughput

0.445

High

675975

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

752214

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

763432

MDJ1
DnaJ homolog 1, mitochondrial

1

9

High-throughput

0.445

High

803112

SSZ1
Ribosome-associated complex subunit SSZ1

1

9

High-throughput

0.445

High

803119

XDJ1
DnaJ protein homolog XDJ1

1

6

High-throughput

0.445

High

803120

FHP
Flavohemoprotein

1

3

High-throughput

0.445

High

803124

HSP7E
Heat shock protein SSC3, mitochondrial

1

10

High-throughput

0.445

High

803128

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

803147

HLJ1
Protein HLJ1

1

3

High-throughput

0.445

High

367959

ENO2
Enolase 2

1

2

High-throughput

0.437

High

410109

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.437

High

420928

PMA1
Plasma membrane ATPase 1

1

5

High-throughput

0.437

High

433017

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.437

High

434011

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.437

High

434157

RL36A
Large ribosomal subunit protein eL36A

1

1

High-throughput

0.437

High

434364

RL15A
Large ribosomal subunit protein eL15A

1

3

High-throughput

0.437

High

434560

RL22A
Large ribosomal subunit protein eL22A

1

2

High-throughput

0.437

High

435561

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.437

High

441889

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.437

High

503784

RL27A
Large ribosomal subunit protein eL27A

1

3

High-throughput

0.437

High

504192

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

511188

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

511411

RL43B
Large ribosomal subunit protein eL43B

1

1

High-throughput

0.437

High

511790

RS24A
Small ribosomal subunit protein eS24A

1

3

High-throughput

0.437

High

512420

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

512989

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

513678

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.437

High

513859

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.437

High

513991

RL18B
Large ribosomal subunit protein eL18B

1

2

High-throughput

0.437

High

514278

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.437

High

515090

RL19B
Large ribosomal subunit protein eL19

1

3

High-throughput

0.437

High

515250

RL35A
Large ribosomal subunit protein uL29A

1

3

High-throughput

0.437

High

582456

SEC23
Protein transport protein SEC23

1

3

High-throughput

0.437

High

597452

EF3A
Elongation factor 3A

1

4

High-throughput

0.437

High

601035

RL8A
Large ribosomal subunit protein eL8A

1

4

High-throughput

0.437

High

616418

SEC18
Vesicular-fusion protein SEC18

1

9

High-throughput

0.437

High

618583

FAS2
Fatty acid synthase subunit alpha

1

1

High-throughput

0.437

High

644768

CLH
Clathrin heavy chain

1

3

High-throughput

0.437

High

655449

RS3A2
Small ribosomal subunit protein eS1B

1

4

High-throughput

0.437

High

689206

RL16B
Large ribosomal subunit protein uL13B

1

3

High-throughput

0.437

High

689434

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

732139

COPG
Coatomer subunit gamma

1

3

High-throughput

0.437

High

734091

EF2
Elongation factor 2

1

6

High-throughput

0.437

High

736092

ARP2
Actin-related protein 2

1

6

High-throughput

0.437

High

747343

RSSA1
Small ribosomal subunit protein uS2A

1

7

High-throughput

0.437

High

753350

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.437

High

781180

RL14A
Large ribosomal subunit protein eL14A

1

1

High-throughput

0.437

High

794969

NU170
Nucleoporin NUP170

1

4

High-throughput

0.437

High

803110

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

4

High-throughput

0.437

High

803116

SEC31
Protein transport protein SEC31

1

8

High-throughput

0.437

High

803123

RS26A
Small ribosomal subunit protein eS26A

1

1

High-throughput

0.437

High

803129

RL13B
Large ribosomal subunit protein eL13B

1

2

High-throughput

0.437

High

803133

SEC24
Protein transport protein SEC24

1

3

High-throughput

0.437

High

803135

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.437

High

803139

COPB
Coatomer subunit beta

1

2

High-throughput

0.437

High

803140

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.437

High

803146

RS7B
Small ribosomal subunit protein eS7B

1

2

High-throughput

0.437

High

803153

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.437

High

803161

ACAC
Acetyl-CoA carboxylase

1

2

High-throughput

0.437

High

803164

RL21A
Large ribosomal subunit protein eL21A

1

1

High-throughput

0.437

High

803165

ESC1
Silent chromatin protein ESC1

1

1

High-throughput

0.437

High

803175

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

803125

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.426

High

803145

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

803148

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

803182

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

577122

SEC63
Protein translocation protein SEC63

1

5

High-throughput

0.407

High

803127

PIC2
Mitochondrial phosphate carrier protein 2

1

6

High-throughput

0.407

High

803136

DJP1
DnaJ-like protein 1

1

4

High-throughput

0.407

High

803150

PHB2
Prohibitin-2

1

9

High-throughput

0.407

High

803137

LCB2
Serine palmitoyltransferase 2

2

0

High-throughput

0.324

High

481884

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

679045

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

733803

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.249

Low

803115

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.249

Low

803154

SHY1
Cytochrome oxidase assembly protein SHY1

1

0

Small-scale

0.249

Low

803168

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.249

Low

803118

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025