HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	35914814
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 605
+	Hs
		1330889 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1302645 Q96T11_HUMAN (1-832): 0: 691: 90.51		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		72802 RIPK4_HUMAN (1-832): 0: 726: 100.00		B4DH70_HUMAN (98-605): 6.62e-144: 428: 85.63
+	Hs
		883666 RIPK4_HUMAN (1-832): 0: 726: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1330876 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1302644 Q96T11_HUMAN (1-832): 0: 691: 90.51		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		883544 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		1163035 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		862124 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1219809 ANKH1_HUMAN (384-541): 3.69e-19: 95.3: 14.47		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		166894 ANR28_HUMAN (252-539): 5.33e-14: 78.4: 10.62		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		903354 ANKH1_HUMAN (384-541): 3.69e-19: 95.3: 14.47		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33