HitPredict

Interactor 1: FBXW4 (P57775)
F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)
Gene: FBXW4

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	30945288
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 759
+	Hs
		1043297 FBW1B_HUMAN (34-411): 3.49e-81: 260: 16.03		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043637 FBW1B_HUMAN (34-411): 3.49e-81: 260: 16.03		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		792982 LIS1_HUMAN (7-322): 9.15e-67: 219: 13.20		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		903208 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043085 WDR5B_HUMAN (33-319): 2.7e-61: 203: 12.80		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		903209 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043441 WDR5B_HUMAN (33-319): 2.7e-61: 203: 12.80		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043114 POC1B_HUMAN (238-411): 3.76e-36: 139: 10.92		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043499 FBXW7_HUMAN (24-276): 1.51e-43: 163: 14.89		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043469 POC1B_HUMAN (238-411): 3.76e-36: 139: 10.92		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		903207 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Mm
		1337557 FBXW4_MOUSE (17-412): 1.41e-83: 263: 91.44		CUL1_MOUSE (59-759): 0: 745: 30.55
+	Hs
		885038 FBXW4_HUMAN (21-412): 3.66e-83: 262: 98.22		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1041266 FBW1B_HUMAN (34-411): 3.49e-81: 260: 16.03		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		903206 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1042101 POC1B_HUMAN (238-411): 3.76e-36: 139: 10.92		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Sp
		142915 POF1_SCHPO (69-411): 1.08e-70: 235: 19.19		CUL1_SCHPO (62-759): 0: 680: 29.27
+	Mm
		1257398 FBXW7_MOUSE (24-276): 6.01e-44: 164: 14.89		CUL1_MOUSE (59-759): 0: 745: 30.55
+	Hs
		1041133 FBXW7_HUMAN (24-276): 1.51e-43: 163: 14.89		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Sp
		142916 POP1_SCHPO (28-411): 1.3e-59: 208: 14.88		CUL1_SCHPO (62-759): 0: 680: 29.27