Protein: DDX52
Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (ATP-dependent RNA helicase ROK1-like) (DEAD box protein 52)

Gene: DDX52
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q9Y2R4

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

373551

MYC
Myc proto-oncogene protein

4

11

High-throughput

0.686

High

1436829

WDR76
WD repeat-containing protein 76

2

12

High-throughput

0.675

High

96796

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.618

High

285532

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

316186

RECQ4
ATP-dependent DNA helicase Q4

1

17

High-throughput

0.618

High

346529

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.618

High

731722

STIP1
Stress-induced-phosphoprotein 1

1

10

High-throughput

0.618

High

1088627

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

12

High-throughput

0.618

High

1106142

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

8

High-throughput

0.618

High

1133061

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

12

High-throughput

0.618

High

1311894

DHX40
Probable ATP-dependent RNA helicase DHX40

1

13

High-throughput

0.618

High

1387652

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

12

High-throughput

0.618

High

1414623

DDX23
Probable ATP-dependent RNA helicase DDX23

1

16

High-throughput

0.618

High

1433484

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.618

High

1450741

DDX18
ATP-dependent RNA helicase DDX18

1

17

High-throughput

0.618

High

447599

NPM
Nucleophosmin

2

2

High-throughput

0.611

High

600218

ZNF22
Zinc finger protein 22

2

1

High-throughput

0.611

High

898894

RL14
Large ribosomal subunit protein eL14

2

1

High-throughput

0.611

High

979358

RS6
Small ribosomal subunit protein eS6

2

5

High-throughput

0.584

High

980572

H4
Histone H4

2

6

High-throughput

0.584

High

1161768

IF16
Gamma-interferon-inducible protein 16

2

3

High-throughput

0.584

High

1447470

ANLN
Anillin

2

4

High-throughput

0.584

High

1212391

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.575

High

397268

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1130538

RRP1B
Ribosomal RNA processing protein 1 homolog B

2

5

High-throughput

0.571

High

1256177

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

1461714

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.553

High

74650

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

9

High-throughput

0.536

High

208429

RRP8
Ribosomal RNA-processing protein 8

1

1

High-throughput

0.536

High

549029

KPSH1
Serine/threonine-protein kinase H1

1

1

High-throughput

0.536

High

785542

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.536

High

833224

MNDA
Myeloid cell nuclear differentiation antigen

1

3

High-throughput

0.536

High

855263

NOP2
28S rRNA

1

2

High-throughput

0.536

High

945733

FOXL2
Forkhead box protein L2

1

6

High-throughput

0.536

High

1006805

SRPK2
SRSF protein kinase 2

1

13

High-throughput

0.536

High

1037448

H11
Histone H1.1

1

1

High-throughput

0.536

High

1057967

RL18
Large ribosomal subunit protein eL18

1

3

High-throughput

0.536

High

1061629

FOXM1
Forkhead box protein M1

1

5

High-throughput

0.536

High

1117715

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.536

High

1291293

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.536

High

1368249

CDKL2
Cyclin-dependent kinase-like 2

1

5

High-throughput

0.536

High

1370481

CSN5
COP9 signalosome complex subunit 5

1

13

High-throughput

0.536

High

1433809

SENP3
Sentrin-specific protease 3

1

4

High-throughput

0.536

High

243339

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.533

High

978419

RHOB
Rho-related GTP-binding protein RhoB

2

8

High-throughput

0.533

High

897558

BPL1
Biotin--protein ligase

1

0

High-throughput

0.518

High

946915

H2B1D
Histone H2B type 1-D

1

3

High-throughput

0.515

High

1163307

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.515

High

443107

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.513

High

1144226

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1453699

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.513

High

1411913

UTP23
rRNA-processing protein UTP23 homolog

1

3

Small-scale

0.501

High

125859

AP4M1
AP-4 complex subunit mu-1

1

3

High-throughput

0.494

High

258479

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.493

High

426602

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

455892

H10
Histone H1.0

1

0

High-throughput

0.493

High

547009

FGF3
Fibroblast growth factor 3

1

3

High-throughput

0.489

High

649458

H1T
Histone H1t

1

1

High-throughput

0.489

High

706357

S10A2
Protein S100-A2

1

4

High-throughput

0.489

High

1016393

SERF2
Small EDRK-rich factor 2

1

1

High-throughput

0.489

High

1091382

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

1196254

GAG2E
G antigen 2E

1

1

High-throughput

0.489

High

1384160

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.489

High

129574

MEN1
Menin

1

4

High-throughput

0.479

High

141175

NOP56
Nucleolar protein 56

1

6

High-throughput

0.479

High

191167

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

223435

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

401730

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

406816

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.479

High

473194

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

12

High-throughput

0.479

High

487899

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

590077

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

644139

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

664836

CCND1
G1/S-specific cyclin-D1

1

3

High-throughput

0.479

High

674383

BRD2
Bromodomain-containing protein 2

1

17

High-throughput

0.479

High

696914

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

720369

UFO
Tyrosine-protein kinase receptor UFO

1

2

High-throughput

0.479

High

769562

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

786945

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

6

High-throughput

0.479

High

789600

PPARG
Peroxisome proliferator-activated receptor gamma

1

15

Small-scale

0.479

High

832595

ETV3
ETS translocation variant 3

1

3

High-throughput

0.479

High

872911

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.479

High

879638

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.479

High

883739

CENPA
Histone H3-like centromeric protein A

1

11

High-throughput

0.479

High

897430

CDK7
Cyclin-dependent kinase 7

1

6

High-throughput

0.479

High

937979

FOXA1
Hepatocyte nuclear factor 3-alpha

1

5

High-throughput

0.479

High

955772

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

967049

1433G
14-3-3 protein gamma

1

9

High-throughput

0.479

High

982884

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.479

High

985077

RL31
Large ribosomal subunit protein eL31

1

5

High-throughput

0.479

High

988843

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

998972

H31
Histone H3.1

1

11

High-throughput

0.479

High

1100564

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

1107355

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1127262

RBM39
RNA-binding protein 39

1

14

High-throughput

0.479

High

1130888

RRP5
Protein RRP5 homolog

1

9

High-throughput

0.479

High

1138183

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

1146880

PCBP1
Poly(rC)-binding protein 1

1

12

High-throughput

0.479

High

1197760

MIDN
Midnolin

1

3

High-throughput

0.479

High

1207464

HABP4
Intracellular hyaluronan-binding protein 4

1

3

High-throughput

0.479

High

1215907

RC3H1
Roquin-1

1

6

High-throughput

0.479

High

1257179

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

1290836

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.479

High

1314490

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1335085

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1352848

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1358315

STAG1
Cohesin subunit SA-1

1

1

High-throughput

0.479

High

1367638

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1393843

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1404851

RING2
E3 ubiquitin-protein ligase RING2

1

11

High-throughput

0.479

High

1406880

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

10

High-throughput

0.479

High

1418648

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

13

High-throughput

0.479

High

1438092

RC3H2
Roquin-2

1

10

High-throughput

0.479

High

1446451

BRD7
Bromodomain-containing protein 7

1

14

High-throughput

0.479

High

1448254

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

1454366

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

7

High-throughput

0.479

High

1459376

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

180112

BET1
BET1 homolog

1

0

High-throughput

0.458

High

631579

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.458

High

693145

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

787104

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.458

High

800179

COIL
Coilin

1

0

High-throughput

0.458

High

1403620

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1415914

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1428678

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1451470

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1453058

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1490878

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

49041

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

294766

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

430535

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

1119381

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

1437418

LN28A
Protein lin-28 homolog A

1

13

High-throughput

0.445

High

1451898

MED29
Mediator of RNA polymerase II transcription subunit 29

1

1

High-throughput

0.445

High

126885

RHOD
Rho-related GTP-binding protein RhoD

1

10

High-throughput

0.437

High

272563

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.437

High

318922

RHBT1
Rho-related BTB domain-containing protein 1

1

13

High-throughput

0.437

High

419281

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

466533

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.437

High

581382

RAC2
Ras-related C3 botulinum toxin substrate 2

1

6

High-throughput

0.437

High

895822

LHX2
LIM/homeobox protein Lhx2

1

1

High-throughput

0.437

High

910262

RND2
Rho-related GTP-binding protein RhoN

1

10

High-throughput

0.437

High

962652

RHOA
Transforming protein RhoA

1

8

High-throughput

0.437

High

1063718

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.437

High

1276997

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1327285

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1379972

LHX4
LIM/homeobox protein Lhx4

1

1

High-throughput

0.437

High

1396662

RHOV
Rho-related GTP-binding protein RhoV

1

7

High-throughput

0.437

High

1433590

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.437

High

1434278

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1438257

RHOF
Rho-related GTP-binding protein RhoF

1

9

High-throughput

0.437

High

1461512

BRPF3
Bromodomain and PHD finger-containing protein 3

1

7

High-throughput

0.437

High

601912

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

1451144

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.426

High

1030393

PMP22
Peripheral myelin protein 22

1

0

High-throughput

0.282

High

1127537

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1219074

RSBN1
Lysine-specific demethylase 9

1

0

High-throughput

0.279

Low

1230920

Z324B
Zinc finger protein 324B

1

0

High-throughput

0.279

Low

1294356

ZN677
Zinc finger protein 677

1

0

High-throughput

0.279

Low

1326757

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

1395741

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1490879

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

869811

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.265

Low

1126218

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1235263

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

1249349

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025