HitPredict

Interactor 1: RN216 (P58283)
E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (UbcM4-interacting protein 83) (Ubiquitin-conjugating enzyme 7-interacting protein 1)
Gene: Rnf216

Interactor 2: UB2L3 (P68037)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (UbcM4) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3)
Gene: Ube2l3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	24945773, 10431818
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 853 Mm			1 154
+	Hs
		1347205 RN216_HUMAN (1-853): 0: 1083: 87.07		UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93
+	Hs
		849460 RN216_HUMAN (1-853): 0: 1083: 87.07		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		919878 RN216_HUMAN (1-853): 0: 1083: 87.07		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		895928 RN216_HUMAN (1-853): 0: 1083: 87.07		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		932585 RN216_HUMAN (1-853): 0: 1083: 87.07		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		159097 RN216_HUMAN (1-853): 0: 1083: 87.07		UB2L6_HUMAN (1-152): 4e-53: 166: 55.26
+	Ce
		137091 ARI11_CAEEL (373-772): 1.03e-127: 394: 15.97		UBC18_CAEEL (1-152): 8.21e-66: 198: 59.21
+	Ce
		137086 O01963_CAEEL (373-772): 1.23e-125: 388: 16.79		UBC18_CAEEL (1-152): 8.21e-66: 198: 59.21
+	Hs
		849498 ARI1_HUMAN (413-772): 9.02e-116: 365: 13.90		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		895968 ARI1_HUMAN (413-772): 9.02e-116: 365: 13.90		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		1297383 ARI1_HUMAN (413-772): 9.02e-116: 365: 13.90		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Ce
		1094319 Q9NA31_CAEEL (373-772): 5.73e-119: 371: 16.91		UBC18_CAEEL (1-152): 8.21e-66: 198: 59.21
+	Ce
		137089 O01964_CAEEL (392-772): 8.99e-119: 371: 16.67		UBC18_CAEEL (1-152): 8.21e-66: 198: 59.21
+	Dm
		1180449 Q9VT94_DROME (373-772): 4.49e-115: 361: 15.42		UBC10_DROME (1-154): 1.1e-67: 203: 74.03
+	Hs
		932603 ARI1_HUMAN (413-772): 9.02e-116: 365: 13.90		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Dm
		1180448 ARI1_DROME (372-772): 1.2e-113: 357: 15.22		UBC10_DROME (1-154): 1.1e-67: 203: 74.03
+	Mm
		932612 ARI1_MOUSE (413-772): 1.07e-115: 364: 13.90		UB2L3_MOUSE (1-154): 1.26e-64: 196: 100.00
+	Hs
		932587 AKIB1_HUMAN (315-762): 1.51e-109: 363: 14.26		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Ce
		88104 D3NQB4_CAEEL (433-772): 1.05e-110: 347: 16.95		UBC18_CAEEL (1-152): 8.21e-66: 198: 59.21
+	Hs
		159108 ARI1_HUMAN (413-772): 9.02e-116: 365: 13.90		UB2L6_HUMAN (1-152): 4e-53: 166: 55.26