HitPredict

Interactor 1: D3ZV15 (D3ZV15)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
Gene: Cbl

Interactor 2: VGFR1 (P53767)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
Gene: Flt1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15001553
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014823 - response to activity GO:0045471 - response to ethanol GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0071456 - cellular response to hypoxia
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Rn			1 1336
+	Mm
		610553 CBL_MOUSE (1-871): 0: 863: 97.47		VGFR1_MOUSE (1-1336): 0: 1003: 92.22
+	Hs
		572586 CBL_HUMAN (1-851): 0: 844: 91.56		VGFR1_HUMAN (1-1335): 0: 981: 82.42
+	Dm
		112207 O46034_DROME (46-457): 0: 746: 70.46		M9MRE1_DROME (26-1308): 0: 590: 22.29
+	Hs
		610268 CBL_HUMAN (1-851): 0: 844: 91.56		FLT3_HUMAN (675-1155): 1.18e-98: 341: 41.02
+	Hs
		557035 CBL_HUMAN (1-851): 0: 844: 91.56		PGFRA_HUMAN (14-550): 2.91e-61: 231: 22.18
+	Hs
		601457 CBL_HUMAN (1-851): 0: 844: 91.56		FGFR2_HUMAN (1-359): 2.12e-54: 207: 13.05
+	Hs
		452353 CBL_HUMAN (1-851): 0: 844: 91.56		PGFRB_HUMAN (25-556): 1.52e-50: 197: 21.28
+	Hs
		610266 CBL_HUMAN (1-851): 0: 844: 91.56		VGFR2_HUMAN (2-438): 5.24e-47: 187: 13.31
+	Mm
		403532 CBL_MOUSE (1-871): 0: 863: 97.47		KIT_MOUSE (7-467): 9.82e-29: 127: 12.12
+	Hs
		426985 CBL_HUMAN (1-851): 0: 844: 91.56		CSF1R_HUMAN (5-415): 6.61e-30: 130: 12.56
+	Mm
		404008 CBL_MOUSE (1-871): 0: 863: 97.47		PGFRB_MOUSE (2-369): 1.2e-21: 104: 12.15
+	Hs
		499234 CBL_HUMAN (1-851): 0: 844: 91.56		KIT_HUMAN (7-467): 1.82e-26: 120: 12.42
+	Mm
		452178 CBL_MOUSE (1-871): 0: 863: 97.47		CSF1R_MOUSE (6-346): 2e-20: 100: 13.12
+	Hs
		452407 CBLB_HUMAN (23-727): 0: 726: 56.50		PGFRB_HUMAN (25-556): 1.52e-50: 197: 21.28
+	Hs
		607879 CBL_HUMAN (1-851): 0: 844: 91.56		FGFR4_HUMAN (2-136): 3.83e-13: 76.5: 11.41
+	Hs
		499262 CBLB_HUMAN (23-727): 0: 726: 56.50		KIT_HUMAN (7-467): 1.82e-26: 120: 12.42
+	Hs
		607956 CBLB_HUMAN (23-727): 0: 726: 56.50		FGFR4_HUMAN (2-136): 3.83e-13: 76.5: 11.41
+	Hs
		608187 CBLC_HUMAN (42-503): 0: 625: 42.16		FGFR4_HUMAN (2-136): 3.83e-13: 76.5: 11.41
+	Hs
		203204 SYNJ1_HUMAN (624-883): 1.05e-10: 68.1: 12.31		FGFR1_HUMAN (2-142): 1.52e-15: 84.2: 7.64
+	Rn
		94375 F1M9G7_RAT (402-830): 1.08e-09: 64.6: 10.96		FGFR1_RAT (2-142): 1.08e-15: 84.6: 7.64