Interactor 1: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Interactor 2: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.899

The method score is based on:

Property Details
Experiments 14976311, 30631154, 26299948, 24766807
Identification Methods affinity chromatography technology, pull down, molecular sieving, x ray scattering, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PTEN_C2~PTEN_C2, PTEN_C2~Y_phosphatase, Y_phosphatase~Y_phosphatase
Common GO terms GO:0001933 - negative regulation of protein phosphorylation
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0004721 - phosphoprotein phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
and 88 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 403
Hs

1 403
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ca
+ Sp
+ Sc
+ Hs

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Last updated: 15 Jul 2024