HitPredict

Interactor 1: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Interactor 2: KBTB6 (Q86V97)
Kelch repeat and BTB domain-containing protein 6
Gene: KBTBD6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.822

Property	Details
Experiments	25684205, 20562859
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	ATG8~KBTB_W-LIR
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 674
+	Hs
		891243 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		306250 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		1262066 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		306221 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		1201303 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		1262059 MLP3C_HUMAN (5-116): 5.09e-45: 144: 42.11		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		1262064 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		1201299 MLP3C_HUMAN (5-116): 5.09e-45: 144: 42.11		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		1201302 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		891139 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		306167 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		1049326 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Dm
		1181841 Q9W2S2_DROME (1-117): 5.35e-58: 176: 57.27		Q7KSF5_DROME (435-671): 1.88e-44: 172: 13.73
+	Hs
		1049329 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		1049322 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		891272 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		KLHL5_HUMAN (312-483): 4.15e-26: 116: 17.51
+	Hs
		1299556 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		KLHL5_HUMAN (312-483): 4.15e-26: 116: 17.51
+	Hs
		1120814 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		KLH12_HUMAN (505-667): 2.1e-22: 103: 13.30
+	Hs
		1120811 MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14		KLH12_HUMAN (505-667): 2.1e-22: 103: 13.30