Protein: EDC4
Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)

Gene: EDC4
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q6P2E9

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1241505

DCP1A
mRNA-decapping enzyme 1A

11

7

Small-scale

0.759

High

1241464

DCP2
m7GpppN-mRNA hydrolase

10

2

Small-scale

0.757

High

1241454

EDC4
Enhancer of mRNA-decapping protein 4

2

10

Small-scale

0.754

High

684276

DDX6
Probable ATP-dependent RNA helicase DDX6

6

8

Small-scale

0.732

High

1241468

XRN1
5'-3' exoribonuclease 1

5

1

Small-scale

0.712

High

1241485

EDC3
Enhancer of mRNA-decapping protein 3

6

0

Small-scale

0.705

High

1241484

SGF29
SAGA-associated factor 29

6

0

High-throughput

0.704

High

791467

SYUA
Alpha-synuclein

4

4

Small-scale

0.696

High

1241467

DCP1B
mRNA-decapping enzyme 1B

4

10

Small-scale

0.692

High

774429

BASI
Basigin

4

3

High-throughput

0.691

High

855651

CRK
Adapter molecule crk

4

7

High-throughput

0.691

High

871955

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

2

High-throughput

0.662

High

1241472

LS14A
Protein LSM14 homolog A

3

2

Small-scale

0.640

High

855888

CRKL
Crk-like protein

2

7

High-throughput

0.628

High

1241506

PNRC2
Proline-rich nuclear receptor coactivator 2

2

1

High-throughput

0.601

High

1241460

PATL1
Protein PAT1 homolog 1

2

4

Small-scale

0.588

High

624080

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

4

High-throughput

0.586

High

1241463

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

2

0

High-throughput

0.585

High

242024

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

588947

RFA2
Replication protein A 32 kDa subunit

2

11

High-throughput

0.584

High

695734

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

6

High-throughput

0.584

High

768452

RFA3
Replication protein A 14 kDa subunit

2

6

High-throughput

0.584

High

1241499

WDR76
WD repeat-containing protein 76

2

12

High-throughput

0.584

High

1241508

ANLN
Anillin

2

5

High-throughput

0.584

High

396339

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

3675

NBDY
Negative regulator of P-body association

1

0

Small-scale

0.561

High

1241465

FBX16
F-box only protein 16

2

3

High-throughput

0.549

High

899978

FXR1
RNA-binding protein FXR1

1

9

High-throughput

0.541

High

900379

FXR2
RNA-binding protein FXR2

1

9

High-throughput

0.541

High

336696

BAG4
BAG family molecular chaperone regulator 4

1

3

High-throughput

0.536

High

347110

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

384451

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.536

High

447121

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

483125

CLCA
Clathrin light chain A

1

2

High-throughput

0.536

High

483353

CLCB
Clathrin light chain B

1

2

High-throughput

0.536

High

535191

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.536

High

540036

BCR
Breakpoint cluster region protein

1

12

High-throughput

0.536

High

650815

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.536

High

652334

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

913520

KIF11
Kinesin-like protein KIF11

1

1

High-throughput

0.536

High

1085964

PNRC1
Proline-rich nuclear receptor coactivator 1

1

1

High-throughput

0.536

High

1115737

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

15

High-throughput

0.536

High

1200239

RHG15
Rho GTPase-activating protein 15

1

1

High-throughput

0.536

High

1214342

SYT6
Synaptotagmin-6

1

1

High-throughput

0.536

High

1241480

RENT1
Regulator of nonsense transcripts 1

1

2

Small-scale

0.536

High

1241486

AURKB
Aurora kinase B

1

2

High-throughput

0.536

High

1241490

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.536

High

1241496

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

5

High-throughput

0.536

High

1241523

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.536

High

471089

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

688265

TTP
mRNA decay activator protein ZFP36

1

0

Small-scale

0.513

High

1026086

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1241475

PPR35
Protein phosphatase 1 regulatory subunit 35

1

0

High-throughput

0.513

High

1241487

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1241489

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1241511

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

1241512

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

1241518

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

955302

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.501

High

964332

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

1012201

RT11
Small ribosomal subunit protein uS11m

1

2

High-throughput

0.489

High

1241459

UBE3B
Ubiquitin-protein ligase E3B

1

5

High-throughput

0.489

High

1241521

AT7L1
Ataxin-7-like protein 1

1

8

High-throughput

0.489

High

1241533

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

1241534

NPTN
Neuroplastin

1

2

High-throughput

0.489

High

1122405

GIT2
ARF GTPase-activating protein GIT2

1

6

High-throughput

0.481

High

1241488

YTDC1
YTH domain-containing protein 1

1

2

High-throughput

0.481

High

129185

MEN1
Menin

1

4

High-throughput

0.479

High

157510

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

172955

XPO1
Exportin-1

1

7

High-throughput

0.479

High

180848

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.479

High

272264

OBSL1
Obscurin-like protein 1

1

9

High-throughput

0.479

High

283493

TAD2A
Transcriptional adapter 2-alpha

1

4

High-throughput

0.479

High

284960

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

9

High-throughput

0.479

High

324933

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

375626

RASK
GTPase KRas

1

10

High-throughput

0.479

High

419037

H2A1B
Histone H2A type 1-B/E

1

5

High-throughput

0.479

High

430045

JUN
Transcription factor Jun

1

17

High-throughput

0.479

High

563923

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

613371

VINC
Vinculin

1

3

High-throughput

0.479

High

730683

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

731399

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

754881

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

765631

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.479

High

830932

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

862228

YAP1
Transcriptional coactivator YAP1

1

12

High-throughput

0.479

High

891206

GSK3A
Glycogen synthase kinase-3 alpha

1

12

High-throughput

0.479

High

891628

GSK3B
Glycogen synthase kinase-3 beta

1

13

High-throughput

0.479

High

897865

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

965029

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.479

High

966477

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

970665

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

979843

H4
Histone H4

1

6

High-throughput

0.479

High

1026430

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1028243

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

1031912

NC2B
Protein Dr1

1

2

High-throughput

0.479

High

1045409

TF65
Transcription factor p65

1

15

High-throughput

0.479

High

1049431

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1096724

RFA4
Replication protein A 30 kDa subunit

1

11

High-throughput

0.479

High

1100021

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.479

High

1100838

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

1101995

PABP4
Polyadenylate-binding protein 4

1

2

High-throughput

0.479

High

1113418

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1159298

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.479

High

1161494

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1215667

RC3H1
Roquin-1

1

3

Small-scale

0.479

High

1241457

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1241458

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1241461

TAD2B
Transcriptional adapter 2-beta

1

1

High-throughput

0.479

High

1241462

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1241466

ZZZ3
ZZ-type zinc finger-containing protein 3

1

1

High-throughput

0.479

High

1241469

RHG18
Rho GTPase-activating protein 18

1

2

High-throughput

0.479

High

1241470

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1241473

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

9

High-throughput

0.479

High

1241478

KAT2A
Histone acetyltransferase KAT2A

1

20

High-throughput

0.479

High

1241479

KAT2B
Histone acetyltransferase KAT2B

1

14

High-throughput

0.479

High

1241481

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.479

High

1241483

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1241491

ATX2
Ataxin-2

1

8

High-throughput

0.479

High

1241493

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

High-throughput

0.479

High

1241495

WWTR1
WW domain-containing transcription regulator protein 1

1

10

High-throughput

0.479

High

1241497

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1241498

CSR2B
Cysteine-rich protein 2-binding protein

1

5

High-throughput

0.479

High

1241500

AGO3
Protein argonaute-3

1

2

Small-scale

0.479

High

1241501

RC3H2
Roquin-2

1

14

High-throughput

0.479

High

1241503

TAF9B
Transcription initiation factor TFIID subunit 9B

1

1

High-throughput

0.479

High

1241504

MOV10
Helicase MOV-10

1

2

High-throughput

0.479

High

1241507

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.479

High

1241509

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1241510

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

1241517

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1241519

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

1241520

BAG5
BAG family molecular chaperone regulator 5

1

3

High-throughput

0.479

High

1241522

YETS2
YEATS domain-containing protein 2

1

14

High-throughput

0.479

High

1241524

TRI33
E3 ubiquitin-protein ligase TRIM33

1

14

High-throughput

0.479

High

1241525

WDR37
WD repeat-containing protein 37

1

10

High-throughput

0.479

High

1241526

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

1

High-throughput

0.479

High

1241529

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

1241530

MARF1
Meiosis regulator and mRNA stability factor 1

1

1

High-throughput

0.479

High

1241531

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

Small-scale

0.479

High

1241532

YTHD2
YTH domain-containing family protein 2

1

4

High-throughput

0.479

High

1241535

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

1

High-throughput

0.479

High

562897

CCL5
C-C motif chemokine 5

1

0

High-throughput

0.460

High

283609

SUPT3
Transcription initiation protein SPT3 homolog

1

0

High-throughput

0.458

High

284836

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.458

High

319155

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.458

High

837672

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

867215

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1106961

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1187033

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

1229528

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1241456

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1241474

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1241482

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.458

High

1241513

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1241514

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

324265

FA13A
Protein FAM13A

1

4

Small-scale

0.457

High

62541

S35F4
Solute carrier family 35 member F4

1

2

High-throughput

0.445

High

178031

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

4

Small-scale

0.445

High

330205

VENTX
Homeobox protein VENTX

1

8

High-throughput

0.445

High

1130305

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

1209286

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1234824

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.445

High

1241477

ESR2
Estrogen receptor beta

1

20

High-throughput

0.445

High

1241494

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

1241515

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

1241527

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

Small-scale

0.445

High

654519

FBLN1
Fibulin-1

1

2

High-throughput

0.439

High

353394

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

412104

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

1241502

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

3

Small-scale

0.437

High

244983

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

1241471

CAMKV
CaM kinase-like vesicle-associated protein

1

0

High-throughput

0.426

High

886963

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.408

High

619836

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.407

High

906293

GPC3
Glypican-3

1

1

High-throughput

0.407

High

1241476

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

3

0

High-throughput

0.347

High

1241528

RT18C
Small ribosomal subunit protein bS18m

2

0

High-throughput

0.313

High

914280

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

932888

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1093469

COASY
Bifunctional coenzyme A synthase

1

0

Small-scale

0.249

Low

1241455

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1241492

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

505288

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low

516103

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

1241516

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025