Protein: GSK3B
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)

Gene: GSK3B
Organism: Mus musculus
Interactions: 70
UniProt ID: Q9WV60

Gene Ontology (top 5):
GO:0000320 - re-entry into mitotic cell cycle
GO:0001558 - regulation of cell growth
GO:0001837 - epithelial to mesenchymal transition
GO:0002039 - p53 binding
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

205276

AXIN1
Axin-1

7

7

Small-scale

0.957

High

1193990

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

3

10

High-throughput

0.861

High

728545

AKT1
RAC-alpha serine/threonine-protein kinase

3

20

Small-scale

0.845

High

1040018

KPCZ
Protein kinase C zeta type

2

20

Small-scale

0.754

High

1298042

Q8C3W2
Receptor tyrosine kinase-like orphan receptor 2

1

10

Small-scale

0.724

High

1490149

EPM2A
Laforin

1

1

Small-scale

0.715

High

312600

AXIN2
Axin-2

1

7

Small-scale

0.713

High

312851

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.691

High

1013721

TNIK
Traf2 and NCK-interacting protein kinase

1

12

High-throughput

0.691

High

1190224

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

5

High-throughput

0.691

High

1209209

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

17

Small-scale

0.691

High

1036100

CTNB1
Catenin beta-1

4

12

Small-scale

0.677

High

148039

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

17

Small-scale

0.665

High

1221588

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.647

High

424723

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

19

Small-scale

0.618

High

963614

CD5R1
Cyclin-dependent kinase 5 activator 1

1

3

Small-scale

0.618

High

1034865

SNAI1
Zinc finger protein SNAI1

1

4

Small-scale

0.618

High

1222676

ACVL1
Activin receptor type-1-like

1

9

High-throughput

0.618

High

1223495

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

13

Small-scale

0.618

High

1298405

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

Small-scale

0.618

High

1408869

TLR3
Toll-like receptor 3

1

3

Small-scale

0.618

High

1455892

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4

1

20

Small-scale

0.618

High

1490164

TBK1
Serine/threonine-protein kinase TBK1

1

19

Small-scale

0.618

High

530946

TAU
Microtubule-associated protein tau

2

12

Small-scale

0.595

High

890102

PSN1
Presenilin-1

2

1

Small-scale

0.595

High

1297034

Q8BNP7
Adenomatous polyposis coli protein

2

5

Small-scale

0.595

High

1440855

PKHO1
Pleckstrin homology domain-containing family O member 1

1

0

Small-scale

0.586

High

382523

P53
Cellular tumor antigen p53

2

6

Small-scale

0.584

High

723749

CTND1
Catenin delta-1

1

20

Small-scale

0.561

High

104657

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

13

High-throughput

0.536

High

1223105

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.536

High

1274231

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.513

High

108000

G3UXW9
COP9 signalosome complex subunit 1

1

3

Small-scale

0.501

High

700415

CEBPB
CCAAT/enhancer-binding protein beta

1

10

Small-scale

0.501

High

1021084

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

1

9

Small-scale

0.501

High

1221501

NF2L2
Nuclear factor erythroid 2-related factor 2

1

9

Small-scale

0.501

High

1362397

ARRB2
Beta-arrestin-2

1

6

Small-scale

0.501

High

1353859

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.480

High

205689

CTND2
Catenin delta-2

1

17

Small-scale

0.479

High

312520

NEMO
NF-kappa-B essential modulator

1

12

Small-scale

0.479

High

582218

INGR1
Interferon gamma receptor 1

1

1

Small-scale

0.479

High

663004

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

838336

STAT3
Signal transducer and activator of transcription 3

1

5

Small-scale

0.479

High

928125

ATX1
Ataxin-1

1

3

High-throughput

0.479

High

958753

CSN2
COP9 signalosome complex subunit 2

1

3

Small-scale

0.479

High

968228

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

High-throughput

0.479

High

999902

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.479

High

1169547

TRI72
Tripartite motif-containing protein 72

1

8

Small-scale

0.479

High

1222696

APC
Adenomatous polyposis coli protein

1

20

Small-scale

0.479

High

1222805

E2F1
Transcription factor E2F1

1

10

Small-scale

0.479

High

1274346

DACT2
Dapper homolog 2

1

2

Small-scale

0.479

High

1283468

WDTC1
WD and tetratricopeptide repeats protein 1

1

10

High-throughput

0.479

High

1283531

DISC1
Disrupted in schizophrenia 1 homolog

1

1

Small-scale

0.479

High

1296461

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

3

High-throughput

0.479

High

1296960

DZIP1
Cilium assembly protein DZIP1

1

20

Small-scale

0.479

High

1297208

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.479

High

1297411

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.479

High

1341589

DACT1
Dapper homolog 1

1

2

Small-scale

0.479

High

1362824

EED
Polycomb protein EED

1

10

High-throughput

0.479

High

1408717

FOXP3
Forkhead box protein P3

1

2

High-throughput

0.479

High

1408774

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

7

Small-scale

0.479

High

1190290

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

0

Small-scale

0.458

High

1221883

SC6A4
Sodium-dependent serotonin transporter

1

0

High-throughput

0.458

High

1225704

ARF
Tumor suppressor ARF

1

0

Small-scale

0.458

High

1296821

TCAM2
TIR domain-containing adapter molecule 2

1

0

Small-scale

0.458

High

1190512

FBW1A
F-box/WD repeat-containing protein 1A

1

11

High-throughput

0.457

High

1409002

BHE41
Class E basic helix-loop-helix protein 41

1

3

High-throughput

0.457

High

778019

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.445

High

1297564

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

1

Small-scale

0.437

High

704304

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025