HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: MRTFA (Q969V6)
Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)
Gene: MRTFA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	34079125, 35271311, 21670154
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~RPEL
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 931
+	Hs
		929962 ACTG_HUMAN (1-375): 0: 601: 98.93		MRTFA_HUMAN (1-931): 7.39e-98: 330: 100.00
+	Hs
		932312 ACTC_HUMAN (2-375): 0: 592: 94.12		MRTFA_HUMAN (1-931): 7.39e-98: 330: 100.00
+	Hs
		554315 ACTBL_HUMAN (2-375): 0: 735: 91.71		MUC1_HUMAN (274-924): 1.77e-38: 157: 12.18
+	Hs
		965115 ACTBL_HUMAN (2-375): 0: 735: 91.71		ANK2_HUMAN (56-918): 7.93e-33: 140: 13.30
+	Hs
		892105 ACTB_HUMAN (1-375): 0: 603: 100.00		MRTFB_HUMAN (1-921): 1.32e-48: 189: 36.25
+	Hs
		930049 ACTG_HUMAN (1-375): 0: 601: 98.93		MRTFB_HUMAN (1-921): 1.32e-48: 189: 36.25
+	Hs
		932446 ACTC_HUMAN (2-375): 0: 592: 94.12		MRTFB_HUMAN (1-921): 1.32e-48: 189: 36.25
+	Hs
		554290 ACTA_HUMAN (2-375): 0: 591: 94.12		MUC1_HUMAN (274-924): 1.77e-38: 157: 12.18
+	Hs
		891699 ACTB_HUMAN (1-375): 0: 603: 100.00		ANK2_HUMAN (56-918): 7.93e-33: 140: 13.30
+	Hs
		891716 ACTB_HUMAN (1-375): 0: 603: 100.00		ZO1_HUMAN (81-852): 7.1e-33: 140: 10.19
+	Hs
		930079 ACTH_HUMAN (2-375): 0: 589: 93.58		ANK2_HUMAN (56-918): 7.93e-33: 140: 13.30
+	Hs
		932156 ACTC_HUMAN (2-375): 0: 592: 94.12		MDC1_HUMAN (193-916): 4.43e-18: 92.4: 9.76
+	Hs
		891882 ACTB_HUMAN (1-375): 0: 603: 100.00		ANKH1_HUMAN (270-879): 5.9e-11: 69: 13.91
+	Hs
		203220 ACTC_HUMAN (2-375): 0: 592: 94.12		SYNJ1_HUMAN (229-625): 3.45e-10: 66.5: 9.20