Protein: UBE4A
Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)

Gene: UBE4A
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q14139

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849328

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.800

High

895793

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.800

High

1048948

UBXN4
UBX domain-containing protein 4

5

3

High-throughput

0.718

High

919726

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.698

High

1048973

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1048947

IP6K1
Inositol hexakisphosphate kinase 1

3

0

High-throughput

0.632

High

271763

PRDM1
PR domain zinc finger protein 1

2

8

High-throughput

0.628

High

601510

FGFR2
Fibroblast growth factor receptor 2

2

6

High-throughput

0.628

High

874917

TERA
Transitional endoplasmic reticulum ATPase

2

7

High-throughput

0.611

High

1048935

MAVS
Mitochondrial antiviral-signaling protein

1

2

High-throughput

0.586

High

890143

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.585

High

409775

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

1048937

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

3

High-throughput

0.574

High

1028469

SLAP1
Src-like-adapter

1

5

Small-scale

0.561

High

1048927

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

0

Small-scale

0.537

High

885157

FOXL2
Forkhead box protein L2

1

4

High-throughput

0.536

High

1021280

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.536

High

1048933

FOXI2
Forkhead box protein I2

1

4

High-throughput

0.536

High

1048953

SPSB4
SPRY domain-containing SOCS box protein 4

1

3

High-throughput

0.536

High

1048957

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

1048959

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.536

High

1048941

SH2D3
SH2 domain-containing protein 3C

2

5

High-throughput

0.521

High

1048956

CLIC6
Chloride intracellular channel protein 6

1

0

High-throughput

0.518

High

260558

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.515

High

825

A0A096LNW4
PRAME family member 9

1

0

High-throughput

0.513

High

327843

CBX7
Chromobox protein homolog 7

1

0

High-throughput

0.513

High

957834

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

1048958

SELS
Selenoprotein S

1

0

High-throughput

0.513

High

486164

GRAB
Granzyme B

1

2

Small-scale

0.501

High

877033

CASP6
Caspase-6

1

2

Small-scale

0.501

High

1048969

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.493

High

362140

ACHA
Acetylcholine receptor subunit alpha

1

1

High-throughput

0.489

High

362197

GLPA
Glycophorin-A

1

1

High-throughput

0.489

High

558723

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

3

High-throughput

0.489

High

1030926

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1048928

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1048954

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

330198

PTTG1
Securin

1

0

Small-scale

0.480

High

381976

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

386715

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

573687

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

940887

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

962778

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

1018951

TP53B
TP53-binding protein 1

1

1

Small-scale

0.479

High

1035430

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.479

High

1035716

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1048929

PCBP1
Poly(rC)-binding protein 1

1

1

Small-scale

0.479

High

1048934

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1048938

GOLI
E3 ubiquitin-protein ligase RNF130

1

5

High-throughput

0.479

High

1048944

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1048949

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1048950

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1048951

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1048952

CUL5
Cullin-5

1

1

High-throughput

0.479

High

1048971

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

310630

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

0

High-throughput

0.458

High

654325

CALX
Calnexin

1

0

High-throughput

0.458

High

1031853

MTA1
Metastasis-associated protein MTA1

1

0

Small-scale

0.458

High

1048968

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1048970

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

665235

EPHA2
Ephrin type-A receptor 2

1

3

Small-scale

0.457

High

575739

VINC
Vinculin

1

1

High-throughput

0.445

High

1048932

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1048967

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

384819

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

574205

BMP7
Bone morphogenetic protein 7

1

2

Small-scale

0.437

High

963944

IL9R
Interleukin-9 receptor

1

2

High-throughput

0.437

High

1048955

DNJC1
DnaJ homolog subfamily C member 1

1

10

High-throughput

0.437

High

236302

B4GT3
Beta-1,4-galactosyltransferase 3

3

0

High-throughput

0.347

High

1048942

PAR16
Protein mono-ADP-ribosyltransferase PARP16

3

0

High-throughput

0.347

High

702224

CD70
CD70 antigen

2

0

High-throughput

0.328

High

1048930

SV2C
Synaptic vesicle glycoprotein 2C

2

0

High-throughput

0.328

High

1048936

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

0

High-throughput

0.328

High

1048943

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

1048945

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

0

Small-scale

0.301

High

68056

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

798141

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

0

High-throughput

0.279

Low

872023

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.279

Low

1048931

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1048939

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.279

Low

1048940

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1048960

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1048961

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

1048962

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

1048963

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1048964

TM134
Transmembrane protein 134

1

0

High-throughput

0.279

Low

1048965

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.279

Low

1048972

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

929766

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

1048946

FAM3C
Protein FAM3C

1

0

Small-scale

0.249

Low

1048966

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024