HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: TMOD3 (Q9NYL9)
Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Gene: TMOD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 33961781, 34079125, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Tropomodulin
Common GO terms	GO:0005856 - cytoskeleton GO:0005912 - adherens junction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 352
+	Hs
		1122520 ACTBL_HUMAN (2-375): 0: 735: 91.71		TMOD3_HUMAN (1-352): 1.04e-142: 409: 100.00
+	Hs
		474856 POTEI_HUMAN (1-375): 0: 731: 91.20		TMOD3_HUMAN (1-352): 1.04e-142: 409: 100.00
+	Hs
		932411 ACTC_HUMAN (2-375): 0: 592: 94.12		TMOD3_HUMAN (1-352): 1.04e-142: 409: 100.00
+	Hs
		915520 ACTA_HUMAN (2-375): 0: 591: 94.12		TMOD3_HUMAN (1-352): 1.04e-142: 409: 100.00
+	Hs
		892077 ACTB_HUMAN (1-375): 0: 603: 100.00		TMOD2_HUMAN (1-352): 7.98e-135: 389: 75.85
+	Hs
		930031 ACTG_HUMAN (1-375): 0: 601: 98.93		TMOD2_HUMAN (1-352): 7.98e-135: 389: 75.85
+	Hs
		932417 ACTC_HUMAN (2-375): 0: 592: 94.12		TMOD2_HUMAN (1-352): 7.98e-135: 389: 75.85
+	Hs
		657477 ACTB_HUMAN (1-375): 0: 603: 100.00		TMOD1_HUMAN (3-348): 9.31e-129: 374: 62.14
+	Hs
		657481 ACTG_HUMAN (1-375): 0: 601: 98.93		TMOD1_HUMAN (3-348): 9.31e-129: 374: 62.14
+	Hs
		657479 ACTA_HUMAN (2-375): 0: 591: 94.12		TMOD1_HUMAN (3-348): 9.31e-129: 374: 62.14
+	Hs
		932227 ACTC_HUMAN (2-375): 0: 592: 94.12		NLRC3_HUMAN (189-312): 3.36e-23: 102: 22.58
+	Hs
		886390 ACTB_HUMAN (1-375): 0: 603: 100.00		NAL12_HUMAN (188-282): 6.81e-11: 65.5: 18.75