HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: TRAF7 (Q6Q0C0)
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
Gene: TRAF7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	34215617, 31478661
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043525 - positive regulation of neuron apoptotic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 670
+	Hs
		564578 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		925367 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		900602 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		545451 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		951210 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60
+	Mm
		892718 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		LIS1_MOUSE (140-426): 1.46e-23: 105: 10.82
+	Hs
		436191 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		LIS1_HUMAN (140-426): 1.68e-23: 105: 10.82
+	Hs
		900348 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		WDR5_HUMAN (99-424): 5.66e-20: 93.7: 10.21
+	Hs
		436239 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		WDR5_HUMAN (99-424): 5.66e-20: 93.7: 10.21