HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1746
+	Hs
		564687 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1330919 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		925619 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		951343 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		900910 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		545621 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		436511 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		892599 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		681775 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568794 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568619 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568605 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568611 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		436148 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568715 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		900861 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PINK1_HUMAN (1357-1669): 2.87e-73: 258: 23.64
+	Hs
		616691 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Ce
		136793 RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		104464 G5EBV3_CAEEL (2-191): 1e-81: 242: 58.95		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		136794 CDC42_CAEEL (1-191): 1.83e-79: 236: 86.39		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80