Protein: SPRC
SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)

Gene: SPRC, SPARC
Organism: Homo sapiens
Interactions: 55
UniProt ID: P09486

Gene Ontology (top 5):
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0005509 - calcium ion binding
GO:0005518 - collagen binding
GO:0005576 - extracellular region
GO:0005604 - basement membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366321

PLMN
Plasminogen

2

2

Small-scale

0.799

High

384092

CO1A1
Collagen alpha-1(I) chain

3

5

Small-scale

0.646

High

384278

CO3A1

2

5

Small-scale

0.629

High

482668

VEGFA
Vascular endothelial growth factor A, long form

2

3

Small-scale

0.602

High

376370

PDGFB
Platelet-derived growth factor subunit B

2

3

Small-scale

0.595

High

482681

RASF7
Ras association domain-containing protein 7

2

0

High-throughput

0.585

High

482697

MYOC
Myocilin

1

3

Small-scale

0.552

High

482669

VCAM1
Vascular cell adhesion protein 1

1

2

Small-scale

0.536

High

482685

ILK
Scaffold protein ILK

1

1

Small-scale

0.536

High

482687

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.536

High

482699

CSTL1
Cystatin-like 1

1

1

High-throughput

0.536

High

482676

TGFR2
TGF-beta receptor type-2

1

5

Small-scale

0.527

High

482683

ILF3
Interleukin enhancer-binding factor 3

1

1

High-throughput

0.515

High

482702

STAB1
Stabilin-1

1

6

Small-scale

0.515

High

482704

TBC14
TBC1 domain family member 14

1

1

High-throughput

0.515

High

482664

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

482680

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.513

High

482686

CASP8
Caspase-8

1

0

Small-scale

0.513

High

399530

VTNC
Vitronectin

1

3

Small-scale

0.501

High

421360

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.501

High

482666

COBA1

1

5

Small-scale

0.501

High

482670

CO5A1

1

5

Small-scale

0.501

High

482672

TENA
Tenascin

1

11

Small-scale

0.501

High

482677

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

5

Small-scale

0.501

High

482689

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

2

High-throughput

0.489

High

482667

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

482691

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

2

Small-scale

0.481

High

482705

UBQL1
Ubiquilin-1

1

2

Small-scale

0.481

High

387692

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

2

Small-scale

0.479

High

400161

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

403058

PDGFA
Platelet-derived growth factor subunit A

1

3

Small-scale

0.479

High

464405

TSP1
Thrombospondin-1

1

5

Small-scale

0.479

High

482688

BGH3
Transforming growth factor-beta-induced protein ig-h3

1

1

Small-scale

0.479

High

482690

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

482678

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

469700

MMP3
Stromelysin-1

1

3

Small-scale

0.445

High

482682

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

4

High-throughput

0.445

High

482696

COCA1

1

10

High-throughput

0.445

High

370988

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

482673

DNMT1
DNA

1

2

Small-scale

0.437

High

183843

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

0

High-throughput

0.426

High

482674

CCN2
CCN family member 2

1

0

High-throughput

0.426

High

482675

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.426

High

482679

CATK
Cathepsin K

1

0

Small-scale

0.426

High

482684

STX3
Syntaxin-3

1

0

High-throughput

0.426

High

482692

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

482701

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.417

High

482695

VP13A
Intermembrane lipid transfer protein VPS13A

1

1

High-throughput

0.407

High

482694

PHOP2
Pyridoxal phosphate phosphatase PHOSPHO2

1

0

High-throughput

0.269

Low

482698

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.269

Low

482693

ZN579
Zinc finger protein 579

1

0

High-throughput

0.265

Low

482665

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

482700

SEBOX
Homeobox protein SEBOX

1

0

Small-scale

0.249

Low

482703

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

482671

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025