HitPredict

Interactor 1: RAB5B (P61020)
Ras-related protein Rab-5B (EC 3.6.5.2)
Gene: RAB5B

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.902

The method score is based on:

Property Details
Experiments 26355680, 18445495, 25605758, 27314038
Identification Methods affinity chromatography technology, two hybrid, protein kinase assay, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Ras, Ras~Roc
Common GO terms GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005768 - endosome
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
and 4 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 215
Hs

1 2527
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024