Protein: S22A2
Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2)

Gene: S22A2, SLC22A2
Organism: Homo sapiens
Interactions: 104
UniProt ID: O15244

Gene Ontology (top 5):
GO:0005275 - amine transmembrane transporter activity
GO:0005277 - acetylcholine transmembrane transporter activity
GO:0005326 - neurotransmitter transmembrane transporter activity
GO:0005886 - plasma membrane
GO:0006812 - monoatomic cation transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

183988

FLVC1
Choline/ethanolamine transporter FLVCR1

1

10

High-throughput

0.691

High

183955

EXT2
Exostosin-2

2

3

High-throughput

0.608

High

183893

FADS1
Acyl-CoA

1

4

High-throughput

0.536

High

183894

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

5

High-throughput

0.536

High

183897

HIP1R
Huntingtin-interacting protein 1-related protein

1

2

High-throughput

0.536

High

183907

SL9A1
Sodium/hydrogen exchanger 1

1

1

High-throughput

0.536

High

183915

GLRB
Glycine receptor subunit beta

1

2

High-throughput

0.536

High

183917

S26A2
Sulfate transporter

1

4

High-throughput

0.536

High

183920

AT8B2
Phospholipid-transporting ATPase ID

1

7

High-throughput

0.536

High

183922

TAP2
Antigen peptide transporter 2

1

8

High-throughput

0.536

High

183924

S20A2
Sodium-dependent phosphate transporter 2

1

2

High-throughput

0.536

High

183936

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.536

High

183938

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

3

High-throughput

0.536

High

183940

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

9

High-throughput

0.536

High

183944

MBOA2
Membrane-bound glycerophospholipid O-acyltransferase 2

1

6

High-throughput

0.536

High

183949

AT11C
Phospholipid-transporting ATPase IG

1

5

High-throughput

0.536

High

183953

CHPT1
Cholinephosphotransferase 1

1

3

High-throughput

0.536

High

183956

S47A1
Multidrug and toxin extrusion protein 1

1

2

High-throughput

0.536

High

183959

S29A1
Equilibrative nucleoside transporter 1

1

3

High-throughput

0.536

High

183975

CNNM1
Metal transporter CNNM1

1

11

High-throughput

0.536

High

183977

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

6

High-throughput

0.536

High

183909

CD9
CD9 antigen

1

6

Small-scale

0.527

High

183891

HYAL3
Hyaluronidase-3

1

0

High-throughput

0.518

High

183914

ETV5
ETS translocation variant 5

1

0

High-throughput

0.518

High

183969

AGO3
Protein argonaute-3

1

0

High-throughput

0.518

High

183987

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.518

High

183896

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.513

High

183905

GP1BB
Platelet glycoprotein Ib beta chain

1

0

High-throughput

0.513

High

183932

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

0

High-throughput

0.513

High

183947

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.513

High

183981

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.513

High

183921

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.494

High

183928

STAR3
StAR-related lipid transfer protein 3

1

3

High-throughput

0.489

High

183931

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

183943

MIC27
MICOS complex subunit MIC27

1

1

High-throughput

0.489

High

183951

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.489

High

183965

ARV1
Protein ARV1

1

1

High-throughput

0.489

High

183970

NEK6
Serine/threonine-protein kinase Nek6

1

1

High-throughput

0.489

High

183974

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

6

High-throughput

0.489

High

183984

CDYL
Chromodomain Y-like protein

1

1

High-throughput

0.489

High

183901

CLPT1
Putative lipid scramblase CLPTM1

1

7

Small-scale

0.481

High

183902

NB5R3
NADH-cytochrome b5 reductase 3

1

1

Small-scale

0.481

High

183903

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

Small-scale

0.481

High

183904

CD63
CD63 antigen

1

6

Small-scale

0.481

High

183911

EF1G
Elongation factor 1-gamma

1

1

Small-scale

0.481

High

183918

ATNG
Sodium/potassium-transporting ATPase subunit gamma

1

2

Small-scale

0.481

High

183925

PDZ1I
PDZK1-interacting protein 1

1

1

Small-scale

0.481

High

183926

FZD5
Frizzled-5

1

3

Small-scale

0.481

High

183930

PDIA6
Protein disulfide-isomerase A6

1

3

Small-scale

0.481

High

183945

LAP4B
Lysosomal-associated transmembrane protein 4B

1

4

Small-scale

0.481

High

183946

S47A2
Multidrug and toxin extrusion protein 2

1

2

Small-scale

0.481

High

183962

TM147
BOS complex subunit TMEM147

1

1

Small-scale

0.481

High

183963

LFG2
Protein lifeguard 2

1

5

Small-scale

0.481

High

183978

T161A
Transmembrane protein 161A

1

3

Small-scale

0.481

High

183986

FIS1
Mitochondrial fission 1 protein

1

1

Small-scale

0.481

High

183890

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

183913

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

183927

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

Small-scale

0.460

High

183941

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.460

High

183942

HRCT1
Histidine-rich carboxyl terminus protein 1

1

0

Small-scale

0.460

High

183967

TM134
Transmembrane protein 134

1

0

Small-scale

0.460

High

183972

S40A1
Ferroportin

1

0

Small-scale

0.460

High

183973

ITM2C
Integral membrane protein 2C

1

0

Small-scale

0.460

High

183982

STX8
Syntaxin-8

1

0

Small-scale

0.460

High

183990

NCOA3
Nuclear receptor coactivator 3

1

0

Small-scale

0.460

High

125978

RB27B
Ras-related protein Rab-27B

1

2

High-throughput

0.445

High

183900

RAB3D
Ras-related protein Rab-3D

1

1

High-throughput

0.445

High

183908

RAB3A
Ras-related protein Rab-3A

1

1

High-throughput

0.445

High

183916

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

6

High-throughput

0.445

High

183923

AMPE
Glutamyl aminopeptidase

1

5

High-throughput

0.445

High

183935

PPM1L
Protein phosphatase 1L

1

1

High-throughput

0.445

High

183958

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

9

High-throughput

0.445

High

183961

PTSS2
Phosphatidylserine synthase 2

1

1

High-throughput

0.445

High

183964

SRBS1
Sorbin and SH3 domain-containing protein 1

1

3

High-throughput

0.445

High

183971

WDR6
tRNA

1

3

High-throughput

0.445

High

183979

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

5

High-throughput

0.445

High

183983

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

1

High-throughput

0.445

High

183906

CCL2
C-C motif chemokine 2

1

1

Small-scale

0.439

High

183912

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

1

Small-scale

0.439

High

183929

LAP4A
Lysosomal-associated transmembrane protein 4A

1

4

Small-scale

0.439

High

183934

TM41B
Transmembrane protein 41B

1

2

Small-scale

0.439

High

183948

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

1

Small-scale

0.439

High

183991

SERP1
Stress-associated endoplasmic reticulum protein 1

1

1

Small-scale

0.439

High

183892

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.426

High

183898

SKAP2
Src kinase-associated phosphoprotein 2

1

0

High-throughput

0.426

High

183939

CARL1
F-actin-uncapping protein LRRC16A

1

0

High-throughput

0.426

High

183950

EHBP1
EH domain-binding protein 1

1

0

High-throughput

0.426

High

183968

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

0

High-throughput

0.426

High

136233

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

5

High-throughput

0.407

High

183895

VINEX
Vinexin

1

2

High-throughput

0.407

High

183952

WDR48
WD repeat-containing protein 48

1

1

High-throughput

0.407

High

183954

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

5

High-throughput

0.407

High

183980

TRM7
tRNA

1

2

High-throughput

0.407

High

183919

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.282

High

183966

CST9L
Cystatin-9-like

1

0

High-throughput

0.282

High

183910

COT2
COUP transcription factor 2

1

0

High-throughput

0.279

Low

183899

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

0

Small-scale

0.251

Low

183933

T176B
Transmembrane protein 176B

1

0

Small-scale

0.251

Low

183960

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

183976

TREX1
Three-prime repair exonuclease 1

1

0

Small-scale

0.251

Low

183985

TMX2
Thioredoxin-related transmembrane protein 2

1

0

Small-scale

0.251

Low

183989

SPCS1
Signal peptidase complex subunit 1

1

0

Small-scale

0.251

Low

183937

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.232

Low

183957

BSCL2
Seipin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025