HitPredict

Interactor 1: LHX2 (P50458)
LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)
Gene: LHX2

Interactor 2: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	32296183, 35140242, 20211142, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000785 - chromatin GO:0001942 - hair follicle development GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0030182 - neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 411
+	Mm
		1000522 LHX2_MOUSE (1-406): 1.32e-100: 306: 99.02		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		1287932 LHX9_HUMAN (1-406): 5.91e-78: 248: 61.82		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		1000520 LHX9_MOUSE (1-406): 1.17e-76: 245: 61.58		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Mm
		237338 LHX2_MOUSE (1-406): 1.32e-100: 306: 99.02		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Mm
		1000512 RBTN1_MOUSE (33-173): 1.94e-39: 140: 41.26		LDB1_MOUSE (1-411): 0: 760: 99.76
+	Hs
		1229355 LHX8_HUMAN (115-394): 2.59e-35: 135: 23.84		LDB1_HUMAN (1-411): 0: 760: 100.00
+	Mm
		237337 LHX9_MOUSE (1-406): 1.17e-76: 245: 61.58		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Dm
		197486 Q9VTW5_DROME (52-388): 9.87e-71: 235: 27.52		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		120081 M9PCA3_DROME (52-388): 9.79e-71: 235: 27.52		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Dm
		197476 Q9VJ37_DROME (1-404): 4.08e-49: 176: 23.19		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		1270094 Q9VJ37_DROME (1-404): 4.08e-49: 176: 23.19		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Dm
		197503 Q9Y0Z9_DROME (1-404): 4.79e-49: 174: 23.43		O18353_DROME (8-391): 0: 594: 56.89
+	Mm
		237329 RBTN1_MOUSE (33-173): 1.94e-39: 140: 41.26		LDB2_MOUSE (44-411): 0: 626: 76.42
+	Hs
		223931 LHX8_HUMAN (115-394): 2.59e-35: 135: 23.84		LDB2_HUMAN (44-411): 0: 620: 76.69
+	Dm
		197453 Q8IQX7_DROME (49-236): 4.81e-37: 140: 33.68		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		197475 Q9VJ00_DROME (111-323): 2.82e-35: 138: 22.22		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		305321 O77284_DROME (49-236): 8.03e-37: 138: 33.68		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Dm
		118250 M9NCY1_DROME (111-323): 1.61e-35: 136: 22.22		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Ce
		112576 LIN11_CAEEL (10-395): 1.07e-53: 185: 25.69		LIDB1_CAEEL (33-408): 2.6e-137: 407: 27.85
+	Ce
		112575 MEC3_CAEEL (44-325): 6.67e-46: 162: 24.03		LIDB1_CAEEL (33-408): 2.6e-137: 407: 27.85