Interactor 1: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M
Interactor 2: ULA1 (Q13564)
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Gene: NAE1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.973 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 17353931, 28581483, 33961781, 35271311, 19250909, 33857374, 17220875, 18652489 |
| Identification Methods | affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | ThiF~UQ_con |
| Common GO terms | GO:0005634 - nucleus GO:0005829 - cytosol GO:0045116 - protein neddylation |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
