Protein: VATA
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (Vacuolar proton pump subunit A) [Cleaved into: Endonuclease PI-SceI (EC 3.1.-.-) (Sce VMA intein) (VMA1-derived endonuclease) (VDE)]

Gene: VATA, VMA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 231
UniProt ID: P17255

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain
GO:0000329 - fungal-type vacuole membrane
GO:0003677 - DNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

591987

VATB
V-type proton ATPase subunit B

12

18

Small-scale

0.978

High

603437

VATD
V-type proton ATPase subunit D

7

10

Small-scale

0.960

High

603407

VATE
V-type proton ATPase subunit E

7

12

Small-scale

0.959

High

603473

VATF
V-type proton ATPase subunit F

6

9

Small-scale

0.943

High

603434

VPP1
V-type proton ATPase subunit a, vacuolar isoform

12

16

Small-scale

0.758

High

603508

VATG
V-type proton ATPase subunit G

9

15

Small-scale

0.747

High

603493

VATH
V-type proton ATPase subunit H

7

9

Small-scale

0.738

High

603428

VATC
V-type proton ATPase subunit C

6

13

Small-scale

0.727

High

603564

OXR1
Oxidation resistance protein 1

2

11

Small-scale

0.714

High

603430

VA0D
V-type proton ATPase subunit d

5

9

Small-scale

0.712

High

603544

RAV2
Regulator of V-ATPase in vacuolar membrane protein 2

4

1

Small-scale

0.683

High

603439

VATL2
V-type proton ATPase subunit c'

4

7

Small-scale

0.676

High

449309

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

3

4

High-throughput

0.671

High

522975

HSP71
Heat shock protein SSA1

4

13

High-throughput

0.666

High

603504

RAV1
Regulator of V-ATPase in vacuolar membrane protein 1

3

7

Small-scale

0.662

High

603451

VPP2
V-type proton ATPase subunit a, Golgi isoform

3

16

Small-scale

0.647

High

392183

HSP82
ATP-dependent molecular chaperone HSP82

3

16

High-throughput

0.633

High

603400

VATA
V-type proton ATPase catalytic subunit A

1

18

High-throughput

0.618

High

603569

RTC5
Restriction of telomere capping protein 5

1

1

High-throughput

0.618

High

603412

SIS1
Protein SIS1

2

6

High-throughput

0.601

High

603513

SKP1
Suppressor of kinetochore protein 1

2

4

Small-scale

0.601

High

603416

VATL1
V-type proton ATPase subunit c

2

7

Small-scale

0.594

High

603515

MCM6
DNA replication licensing factor MCM6

2

5

High-throughput

0.588

High

603410

VATO
V-type proton ATPase subunit c''

2

7

Small-scale

0.584

High

603433

HOG1
Mitogen-activated protein kinase HOG1

2

9

High-throughput

0.584

High

603547

RRP5
rRNA biogenesis protein RRP5

1

6

High-throughput

0.575

High

364316

CDK1
Cyclin-dependent kinase 1

2

7

High-throughput

0.571

High

578790

HSC82
ATP-dependent molecular chaperone HSC82

2

16

High-throughput

0.571

High

603538

GCN5
Histone acetyltransferase GCN5

2

5

High-throughput

0.549

High

603452

VRP1
Verprolin

2

6

High-throughput

0.537

High

603467

POP2
Poly(A) ribonuclease POP2

2

1

High-throughput

0.537

High

603472

XDJ1
DnaJ protein homolog XDJ1

2

6

High-throughput

0.537

High

603495

EMW1
Essential for maintenance of the cell wall protein 1

2

10

High-throughput

0.537

High

449276

RAD10
DNA repair protein RAD10

1

1

High-throughput

0.536

High

459007

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.536

High

555225

RAD50
DNA repair protein RAD50

1

5

High-throughput

0.536

High

603402

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

9

High-throughput

0.536

High

603408

DBF2
Cell cycle protein kinase DBF2

1

13

High-throughput

0.536

High

603421

CDC15
Cell division control protein 15

1

7

High-throughput

0.536

High

603429

KNS1
Dual specificity protein kinase KNS1

1

11

High-throughput

0.536

High

603438

ELM1
Serine/threonine-protein kinase ELM1

1

7

High-throughput

0.536

High

603484

RAD26
DNA repair and recombination protein RAD26

1

9

High-throughput

0.536

High

603522

BRE5
UBP3-associated protein BRE5

1

6

High-throughput

0.536

High

603531

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

7

High-throughput

0.536

High

603498

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.533

High

603460

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.513

High

517883

SSBP1
Single-stranded nucleic acid-binding protein

1

5

High-throughput

0.501

High

603415

DMC1
Meiotic recombination protein DMC1

1

6

High-throughput

0.500

High

486402

TBA3
Tubulin alpha-3 chain

1

4

High-throughput

0.489

High

561701

HAP3
Transcriptional activator HAP3

1

1

High-throughput

0.489

High

603417

GID7
GID complex subunit 7

1

8

High-throughput

0.489

High

603450

MAOM
NAD-dependent malic enzyme, mitochondrial

1

3

High-throughput

0.489

High

603458

SIF2
SIR4-interacting protein SIF2

1

12

High-throughput

0.489

High

603466

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.489

High

603485

NTA1
Protein N-terminal amidase

1

1

High-throughput

0.489

High

603486

UTP18
U3 small nucleolar RNA-associated protein 18

1

1

High-throughput

0.489

High

603487

NDC80
Kinetochore protein NDC80

1

7

High-throughput

0.489

High

603489

MET18
DNA repair/transcription protein MET18/MMS19

1

2

High-throughput

0.489

High

603499

SA155
SIT4-associating protein SAP155

1

5

High-throughput

0.489

High

603510

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

High-throughput

0.489

High

603551

UTP13
U3 small nucleolar RNA-associated protein 13

1

16

High-throughput

0.489

High

603557

PRP11
Pre-mRNA-splicing factor PRP11

1

2

High-throughput

0.489

High

603559

VPS13
Intermembrane lipid transfer protein VPS13

1

7

High-throughput

0.489

High

603575

IES3
Ino eighty subunit 3

1

3

High-throughput

0.489

High

401870

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

7

High-throughput

0.479

High

430775

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

Small-scale

0.479

High

438611

SC160
Protein SCP160

1

4

High-throughput

0.479

High

441684

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

464545

PBS2
MAP kinase kinase PBS2

1

16

High-throughput

0.479

High

510160

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.479

High

525851

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.479

High

547026

PPB
Repressible alkaline phosphatase

1

1

High-throughput

0.479

High

548881

SCH9
Serine/threonine-protein kinase SCH9

1

11

Small-scale

0.479

High

575716

BPT1
Bile pigment transporter 1

1

8

High-throughput

0.479

High

603406

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.479

High

603418

CDC48
Cell division control protein 48

1

10

High-throughput

0.479

High

603420

PHO91
Low-affinity phosphate transporter PHO91

1

4

High-throughput

0.479

High

603431

YBT1
ATP-dependent bile acid permease

1

5

High-throughput

0.479

High

603441

PRS6A
26S proteasome regulatory subunit 6A

1

9

High-throughput

0.479

High

603456

ATG8
Autophagy-related protein 8

1

12

High-throughput

0.479

High

603457

PFF1
Vacuolar membrane protease

1

3

High-throughput

0.479

High

603462

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

603469

TCPB
T-complex protein 1 subunit beta

1

17

High-throughput

0.479

High

603470

TCPG
T-complex protein 1 subunit gamma

1

15

High-throughput

0.479

High

603471

TCPZ
T-complex protein 1 subunit zeta

1

12

High-throughput

0.479

High

603474

DHH1
ATP-dependent RNA helicase DHH1

1

7

High-throughput

0.479

High

603478

KC13
Casein kinase I homolog 3

1

15

High-throughput

0.479

High

603481

VTC1
Vacuolar transporter chaperone complex subunit 1

1

6

High-throughput

0.479

High

603491

SYG1
Protein SYG1

1

4

High-throughput

0.479

High

603494

VNX1
Low affinity vacuolar monovalent cation/H(+) antiporter

1

3

High-throughput

0.479

High

603496

TCPH
T-complex protein 1 subunit eta

1

14

High-throughput

0.479

High

603497

VTC2
Vacuolar transporter chaperone complex subunit 2

1

9

High-throughput

0.479

High

603501

MPS3
Spindle pole body assembly component MPS3

1

3

High-throughput

0.479

High

603502

VTC4
Vacuolar transporter chaperone complex subunit 4

1

9

High-throughput

0.479

High

603503

TCPQ
T-complex protein 1 subunit theta

1

15

High-throughput

0.479

High

603517

PESC
Pescadillo homolog

1

3

High-throughput

0.479

High

603518

VSB1
Vacuolar basic amino acid transporter VSB1

1

2

High-throughput

0.479

High

603534

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

9

High-throughput

0.479

High

603539

RMD1
Sporulation protein RMD1

1

3

High-throughput

0.479

High

603543

RUVB1
RuvB-like protein 1

1

7

High-throughput

0.479

High

603545

VBA4
Vacuolar basic amino acid transporter 4

1

1

High-throughput

0.479

High

603546

POB3
FACT complex subunit POB3

1

2

High-throughput

0.479

High

603552

TFC6
Transcription factor tau 91 kDa subunit

1

3

High-throughput

0.479

High

603554

CSC1
Calcium permeable stress-gated cation channel 1

1

4

High-throughput

0.479

High

603566

TMA46
Translation machinery-associated protein 46

1

2

High-throughput

0.479

High

603568

SMF3
Iron transporter SMF3

1

2

High-throughput

0.479

High

603570

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

603576

DBP10
ATP-dependent RNA helicase DBP10

1

10

High-throughput

0.479

High

603577

RUVB2
RuvB-like protein 2

1

7

High-throughput

0.479

High

603582

VCX1
Vacuolar calcium ion transporter

1

3

High-throughput

0.479

High

444824

SIR3
Regulatory protein SIR3

1

3

High-throughput

0.470

High

439501

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.458

High

603572

YRA1
RNA annealing protein YRA1

1

0

Small-scale

0.458

High

603573

YVC1
Calcium channel YVC1

1

0

High-throughput

0.458

High

575299

EI2BA
Translation initiation factor eIF2B subunit alpha

1

3

High-throughput

0.457

High

576930

AMPL
Vacuolar aminopeptidase 1

1

1

High-throughput

0.457

High

603405

PP11
Serine/threonine-protein phosphatase PP1-1

1

3

High-throughput

0.457

High

603413

RV161
Reduced viability upon starvation protein 161

1

6

High-throughput

0.457

High

417021

VDAC1
Non-selective voltage-gated ion channel 1

1

5

High-throughput

0.445

High

481466

HSP73
Heat shock protein SSA3

1

12

High-throughput

0.445

High

543730

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

553939

TCPA
T-complex protein 1 subunit alpha

1

16

High-throughput

0.445

High

597704

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

2

High-throughput

0.445

High

603404

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

2

High-throughput

0.445

High

603409

NPR1
Nitrogen permease reactivator protein

1

16

High-throughput

0.445

High

603426

MCM5
Minichromosome maintenance protein 5

1

7

High-throughput

0.445

High

603435

SMI1
Cell wall assembly regulator SMI1

1

2

High-throughput

0.445

High

603436

HSP7F
Heat shock protein homolog SSE1

1

18

High-throughput

0.445

High

603464

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

603479

HSP7E
Heat shock protein SSC3, mitochondrial

1

8

High-throughput

0.445

High

603483

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

603506

JSN1
Protein JSN1

1

3

High-throughput

0.445

High

603521

DBP6
ATP-dependent RNA helicase DBP6

1

2

High-throughput

0.445

High

603541

WDR59
Maintenance of telomere capping protein 5

1

13

High-throughput

0.445

High

149564

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

383497

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.437

High

409916

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433424

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

434796

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.437

High

435750

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

454851

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

502829

RS22A
Small ribosomal subunit protein uS8A

1

4

High-throughput

0.437

High

504019

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

512236

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

512795

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

514434

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

558566

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

603401

PDI
Protein disulfide-isomerase

1

5

High-throughput

0.437

High

603403

IRA2
Inhibitory regulator protein IRA2

1

3

Small-scale

0.437

High

603414

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.437

High

603419

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.437

High

603423

PEX3
Peroxisomal biogenesis factor 3

1

2

High-throughput

0.437

High

603424

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

603425

BMH1
Protein BMH1

1

10

High-throughput

0.437

High

603440

SMY2
Protein SMY2

1

3

High-throughput

0.437

High

603443

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

603444

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

8

High-throughput

0.437

High

603446

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

603447

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

603448

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.437

High

603449

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.437

High

603453

GBLP
Small ribosomal subunit protein RACK1

1

12

High-throughput

0.437

High

603459

GID4
GID complex substrate-recognition subunit 4

1

3

High-throughput

0.437

High

603461

AIM4
Altered inheritance of mitochondria protein 4

1

2

High-throughput

0.437

High

603463

RPN1
26S proteasome regulatory subunit RPN1

1

4

High-throughput

0.437

High

603465

RPN10
26S proteasome regulatory subunit RPN10

1

6

High-throughput

0.437

High

603476

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

603488

TM108
Protein TMA108

1

7

High-throughput

0.437

High

603490

FIS1
Mitochondrial fission 1 protein

1

2

Small-scale

0.437

High

603492

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.437

High

603500

RMD8
Sporulation protein RMD8

1

3

High-throughput

0.437

High

603505

MOG1
Nuclear import protein MOG1

1

3

High-throughput

0.437

High

603507

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.437

High

603509

TOM22
Mitochondrial import receptor subunit TOM22

1

2

High-throughput

0.437

High

603512

INP52
Polyphosphatidylinositol phosphatase INP52

1

3

High-throughput

0.437

High

603516

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

3

High-throughput

0.437

High

603529

SAM50
Sorting assembly machinery 50 kDa subunit

1

3

High-throughput

0.437

High

603530

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.437

High

603532

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

603537

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.437

High

603553

URN1
Pre-mRNA-splicing factor URN1

1

2

High-throughput

0.437

High

603560

SGO1
Shugoshin

1

3

High-throughput

0.437

High

603561

MCA1
Metacaspase-1

1

2

High-throughput

0.437

High

603562

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

603563

AP3D
AP-3 complex subunit delta

1

7

High-throughput

0.437

High

603571

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.437

High

603580

VA0E
V-type proton ATPase subunit e

1

0

Small-scale

0.426

High

150255

RPN13
26S proteasome regulatory subunit RPN13

1

1

High-throughput

0.407

High

454073

DHE4
NADP-specific glutamate dehydrogenase 1

1

2

High-throughput

0.407

High

600648

SEC2
Rab guanine nucleotide exchange factor SEC2

1

1

High-throughput

0.407

High

603411

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

2

High-throughput

0.407

High

603422

LAC1
Ceramide synthase LAC1

1

4

High-throughput

0.407

High

603432

APE2
Aminopeptidase 2, mitochondrial

1

7

High-throughput

0.407

High

603442

MFT1
THO complex subunit MFT1

1

2

High-throughput

0.407

High

603445

SPT7
SAGA complex subunit SPT7

1

4

High-throughput

0.407

High

603454

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

11

High-throughput

0.407

High

603455

SEA4
SEH-associated protein 4

1

2

High-throughput

0.407

High

603477

RV167
Reduced viability upon starvation protein 167

1

9

High-throughput

0.407

High

603482

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

2

High-throughput

0.407

High

603514

NIF3
NGG1-interacting factor 3

1

1

High-throughput

0.407

High

603519

ZNG1
Zinc-regulated GTPase metalloprotein activator 1

1

2

High-throughput

0.407

High

603520

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

1

High-throughput

0.407

High

603523

HCH1
Hsp90 co-chaperone HCH1

1

6

High-throughput

0.407

High

603525

RM22
Large ribosomal subunit protein uL22m

1

2

High-throughput

0.407

High

603526

NOP13
Nucleolar protein 13

1

7

High-throughput

0.407

High

603533

ADA2
SAGA complex subunit ADA2

1

2

High-throughput

0.407

High

603535

SVL3
Styryl dye vacuolar localization protein 3

1

2

High-throughput

0.407

High

603540

ACL4
Assembly chaperone of RPL4

1

1

High-throughput

0.407

High

603549

BCH1
Protein BCH1

1

2

High-throughput

0.407

High

603550

YL287
Uncharacterized protein YLR287C

1

2

High-throughput

0.407

High

603555

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.407

High

603556

SSK1
Osmolarity two-component system protein SSK1

1

5

High-throughput

0.407

High

603567

HFI1
SAGA complex subunit HFI1

1

2

High-throughput

0.407

High

603528

PFD4
Prefoldin subunit 4

2

0

High-throughput

0.307

High

603480

YEC3
Uncharacterized protein YEL023C

1

0

High-throughput

0.269

Low

603565

YIG1
Protein YIG1

1

0

High-throughput

0.269

Low

603574

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.261

Low

603524

PDR17
Phosphatidylinositol transfer protein PDR17

1

0

High-throughput

0.249

Low

603542

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

603578

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.249

Low

603427

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.232

Low

603468

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.232

Low

603475

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

603511

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.232

Low

603527

MDG1
Signal transduction protein MDG1

1

0

High-throughput

0.232

Low

603536

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.232

Low

603548

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

603558

CYK3
Cytokinesis protein 3

1

0

High-throughput

0.232

Low

603579

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low

603581

DET1
Broad-range acid phosphatase DET1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025