HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	17426036, 23695783
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 353
+	Hs
		1151762 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		Q6GX22_HUMAN (14-337): 5.23e-87: 277: 23.68
+	Hs
		1317493 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		1336390 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI39_HUMAN (14-352): 5.49e-70: 229: 16.80
+	Hs
		537142 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		1285831 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI43_HUMAN (10-351): 1.53e-67: 220: 13.74
+	Hs
		175730 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI18_HUMAN (43-337): 4.87e-65: 219: 23.65
+	Hs
		175653 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI18_HUMAN (43-337): 4.87e-65: 219: 23.65
+	Hs
		1318358 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM8_HUMAN (15-330): 6.11e-65: 216: 20.87
+	Hs
		1318738 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM2_HUMAN (10-330): 1.64e-63: 216: 19.52
+	Hs
		1318719 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM5_HUMAN (10-346): 1.16e-64: 214: 17.49
+	Hs
		135045 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI38_HUMAN (8-352): 1.89e-63: 210: 17.68
+	Hs
		262201 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM3_HUMAN (9-346): 3.33e-61: 210: 17.53
+	Hs
		135012 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI38_HUMAN (8-352): 1.89e-63: 210: 17.68
+	Hs
		1354526 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI10_HUMAN (8-353): 7.42e-63: 209: 16.53
+	Hs
		1377469 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI17_HUMAN (8-344): 5.84e-63: 209: 19.88
+	Hs
		262161 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRIM3_HUMAN (9-346): 3.33e-61: 210: 17.53
+	Hs
		1356055 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM1_HUMAN (14-345): 3.61e-59: 205: 22.00
+	Hs
		1318532 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI31_HUMAN (8-301): 3.28e-59: 198: 21.77
+	Hs
		1313765 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI62_HUMAN (16-286): 7.47e-58: 196: 22.71
+	Hs
		1204911 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI50_HUMAN (14-250): 3.59e-14: 75.1: 25.00