HitPredict

Interactor 1: ACTN3 (Q08043)
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
Gene: ACTN3

Interactor 2: ACTN3 (Q08043)
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
Gene: ACTN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 25416956, 32296183, unassigned1304
Identification Methods two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~CH, CH~EFhand_Ca_insen, CH~Spectrin, EFhand_Ca_insen~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, Spectrin~Spectrin
Common GO terms GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005884 - actin filament
GO:0005886 - plasma membrane
and 31 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 901
Hs

1 901
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024