HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: PELI1 (Q96FA3)
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)
Gene: PELI1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	36179399, 21204785, 19734906
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction, ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 152 Hs			1 418
+	Hs
		849407 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		PELI1_HUMAN (1-418): 0: 817: 100.00
+	Hs
		919823 UB2D2_HUMAN (4-149): 9.96e-80: 233: 46.58		PELI1_HUMAN (1-418): 0: 817: 100.00
+	Hs
		895877 UB2D3_HUMAN (4-149): 1.46e-78: 230: 45.89		PELI1_HUMAN (1-418): 0: 817: 100.00
+	Hs
		896491 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		PELI3_HUMAN (3-418): 0: 696: 66.67