HitPredict

Interactor 1: CSN2 (P61201)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: COPS2

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	26976604, 28514442, 32047038, 33961781, 16045761, 34878901, 35563538, 21145461, 19295130, 37207277
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 443 Hs			1 768
+	Hs
		1041600 PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1024159 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL3_HUMAN (1-768): 0: 951: 100.00
+	At
		1258869 CSN2_ARATH (12-442): 5.56e-115: 345: 61.20		CUL3A_ARATH (9-768): 0: 842: 51.45
+	Hs
		897245 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		897246 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Mm
		897343 CSN2_MOUSE (1-443): 3.15e-127: 377: 100.00		CUL1_MOUSE (17-768): 0: 709: 30.53
+	Hs
		897242 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	At
		1258866 CSN2_ARATH (12-442): 5.56e-115: 345: 61.20		CUL1_ARATH (16-768): 0: 728: 30.22
+	Hs
		122005 PSD12_HUMAN (39-440): 8.69e-83: 263: 12.80		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		897243 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1024160 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1024161 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		87385 C9JFE4_HUMAN (17-443): 1.42e-78: 253: 14.93		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		897289 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		1024157 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Sp
		142919 CSN2_SCHPO (4-440): 7.31e-88: 276: 45.70		CUL1_SCHPO (15-768): 0: 672: 28.29
+	Hs
		1041179 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1024158 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1041454 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1024200 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL5_HUMAN (25-768): 0: 597: 23.77