HitPredict

Interactor 1: CSN2 (P61201)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: COPS2

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.762

Property	Details
Experiments	25349427, 26186194, 27029275, 26976604, 28514442, 32047038, 32493769, 33961781, 31973889, 16964240, 18606781, 21145461, 19295130
Identification Methods	pull down, affinity chromatography technology, fluorescent resonance energy transfer, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 443 Hs			1 759
+	Hs
		897246 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		122005 PSD12_HUMAN (39-440): 8.69e-83: 263: 12.80		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1024160 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	At
		1258869 CSN2_ARATH (12-442): 5.56e-115: 345: 61.20		CUL3A_ARATH (36-759): 0: 853: 38.26
+	Hs
		897244 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1024161 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		87385 C9JFE4_HUMAN (17-443): 1.42e-78: 253: 14.93		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		897242 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Mm
		897343 CSN2_MOUSE (1-443): 3.15e-127: 377: 100.00		CUL1_MOUSE (59-759): 0: 745: 30.55
+	At
		1258866 CSN2_ARATH (12-442): 5.56e-115: 345: 61.20		CUL1_ARATH (57-759): 0: 744: 34.20
+	Hs
		897243 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		1041600 PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1024159 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1024157 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1041179 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1024158 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		897289 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Sp
		142919 CSN2_SCHPO (4-440): 7.31e-88: 276: 45.70		CUL1_SCHPO (62-759): 0: 680: 29.27
+	Hs
		1041454 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		1024200 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL5_HUMAN (59-759): 0: 589: 24.94