HitPredict

Interactor 1: LHX5 (P61375)
LIM/homeobox protein Lhx5 (LIM homeobox protein 5)
Gene: LHX5

Interactor 2: LDB1 (P70662)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (mLdb1) (Nuclear LIM interactor)
Gene: LDB1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0005634 - nucleus GO:0021549 - cerebellum development GO:0021702 - cerebellar Purkinje cell differentiation GO:0030182 - neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 402 Mm			1 411
+	Hs
		822644 LHX1_HUMAN (2-402): 1.18e-81: 258: 72.48		LDB1_HUMAN (1-411): 0: 760: 99.76
+	Mm
		925846 LHX1_MOUSE (2-402): 4.63e-82: 258: 72.24		LDB1_MOUSE (1-411): 0: 760: 100.00
+	Hs
		1199128 LHX4_HUMAN (2-400): 3.22e-66: 217: 29.75		LDB1_HUMAN (1-411): 0: 760: 99.76
+	Mm
		864804 LHX4_MOUSE (2-400): 2.95e-66: 217: 29.75		LDB1_MOUSE (1-411): 0: 760: 100.00
+	Hs
		1199146 LHX3_HUMAN (2-379): 1.42e-62: 208: 34.55		LDB1_HUMAN (1-411): 0: 760: 99.76
+	Mm
		936889 LMX1A_MOUSE (3-359): 1.22e-59: 200: 27.73		LDB1_MOUSE (1-411): 0: 760: 100.00
+	Mm
		839896 LHX3_MOUSE (2-379): 8.25e-59: 198: 32.99		LDB1_MOUSE (1-411): 0: 760: 100.00
+	Hs
		238112 LMX1B_HUMAN (3-330): 1.58e-57: 195: 28.79		LDB1_HUMAN (1-411): 0: 760: 99.76
+	Mm
		291994 LMX1B_MOUSE (3-347): 1.01e-57: 195: 28.65		LDB1_MOUSE (1-411): 0: 760: 100.00
+	Mm
		223247 LHX5_MOUSE (1-402): 3.03e-102: 310: 100.00		LDB2_MOUSE (44-411): 0: 626: 76.15
+	Mm
		223249 LHX1_MOUSE (2-402): 4.63e-82: 258: 72.24		LDB2_MOUSE (44-411): 0: 626: 76.15
+	Mm
		223245 LHX4_MOUSE (2-400): 2.95e-66: 217: 29.75		LDB2_MOUSE (44-411): 0: 626: 76.15
+	Hs
		210841 LHX4_HUMAN (2-400): 3.22e-66: 217: 29.75		LDB2_HUMAN (44-411): 0: 620: 76.42
+	Mm
		223259 LMX1A_MOUSE (3-359): 1.22e-59: 200: 27.73		LDB2_MOUSE (44-411): 0: 626: 76.15
+	Mm
		223242 LMX1B_MOUSE (3-347): 1.01e-57: 195: 28.65		LDB2_MOUSE (44-411): 0: 626: 76.15
+	Dm
		185755 Q9V472_DROME (5-376): 7.03e-60: 204: 41.73		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		1182724 Q9V472_DROME (5-376): 7.03e-60: 204: 41.73		Q7KVG9_DROME (8-391): 0: 593: 56.89
+	Dm
		114750 M9PD53_DROME (2-384): 6.53e-58: 199: 31.58		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		185759 Q9VJ00_DROME (2-384): 1.5e-57: 198: 31.58		O18353_DROME (8-391): 0: 594: 56.89
+	Dm
		112541 M9NCY1_DROME (2-384): 1.98e-58: 197: 31.58		Q7KVG9_DROME (8-391): 0: 593: 56.89