HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PKHG6 (Q3KR16)
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
Gene: PLEKHG6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0030054 - cell junction GO:0032154 - cleavage furrow
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 790
+	Hs
		297123 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG5_HUMAN (2-774): 2.55e-119: 385: 32.57
+	Mm
		1146468 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		PKHG5_MOUSE (2-774): 1.42e-109: 361: 32.93
+	Hs
		900768 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG2_HUMAN (8-772): 2.09e-98: 329: 16.22
+	Hs
		900417 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		AKP13_HUMAN (8-755): 1.47e-88: 308: 15.49
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (81-644): 5.43e-90: 304: 17.50
+	Hs
		900612 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGI_HUMAN (5-780): 1.04e-86: 301: 14.32
+	Sp
		1000081 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF2_SCHPO (75-471): 8.95e-74: 263: 23.63
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (99-662): 1.12e-87: 297: 14.98
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (22-750): 2.8e-83: 292: 17.48
+	Hs
		900679 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARG28_HUMAN (8-781): 8.97e-81: 285: 15.11
+	Sp
		1000084 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF1_SCHPO (113-522): 5.04e-68: 247: 21.68
+	Sp
		1336810 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		RGF1_SCHPO (113-522): 5.04e-68: 247: 21.68
+	Hs
		900916 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ECT2_HUMAN (77-645): 3.51e-80: 277: 19.26
+	Hs
		900947 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG4_HUMAN (120-572): 1.48e-78: 268: 16.21
+	Hs
		900765 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG1_HUMAN (130-566): 3.51e-74: 261: 22.83
+	Hs
		900985 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGC_HUMAN (126-539): 1.73e-71: 257: 20.37
+	Hs
		900786 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGQ_HUMAN (127-518): 1.06e-71: 253: 20.14
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (150-719): 1.63e-60: 225: 14.66
+	Hs
		900636 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG8_HUMAN (145-554): 3.83e-60: 216: 20.37
+	Hs
		500932 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2_HUMAN (162-356): 3.28e-09: 62.8: 28.28