Protein: ZO1
Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)

Gene: ZO1, Tjp1
Organism: Mus musculus
Interactions: 42
UniProt ID: P39447

Gene Ontology (top 5):
GO:0001825 - blastocyst formation
GO:0005516 - calmodulin binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

811951

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

20

High-throughput

0.691

High

811939

ACTN4
Alpha-actinin-4

1

13

Small-scale

0.665

High

655034

CXA1
Gap junction alpha-1 protein

3

20

Small-scale

0.640

High

556483

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

1

High-throughput

0.618

High

811946

SRC8
Src substrate cortactin

1

11

Small-scale

0.618

High

811955

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.618

High

811952

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

2

12

High-throughput

0.584

High

312569

CLD1
Claudin-1

2

20

Small-scale

0.576

High

811942

TNIK
Traf2 and NCK-interacting protein kinase

1

20

High-throughput

0.536

High

811950

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

2

High-throughput

0.536

High

811948

VINC
Vinculin

1

10

Small-scale

0.526

High

811941

CXB6
Gap junction beta-6 protein

1

20

Small-scale

0.515

High

73149

SCN7A
Sodium channel protein type 7 subunit alpha

1

5

Small-scale

0.501

High

147723

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

8

High-throughput

0.479

High

204068

CLD4
Claudin-4

1

20

Small-scale

0.479

High

236741

CLD5
Claudin-5

1

20

Small-scale

0.479

High

312573

CLD2
Claudin-2

1

20

Small-scale

0.479

High

313333

COR1A
Coronin-1A

1

1

High-throughput

0.479

High

486813

CADH1
Cadherin-1

1

9

Small-scale

0.479

High

684456

CTNA1
Catenin alpha-1

1

9

Small-scale

0.479

High

771439

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

20

High-throughput

0.479

High

811940

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.479

High

811944

CTNB1
Catenin beta-1

1

9

Small-scale

0.479

High

811945

CDKL5
Cyclin-dependent kinase-like 5

1

14

High-throughput

0.479

High

811947

OCLN
Occludin

1

11

Small-scale

0.479

High

811953

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.479

High

811957

OTU7A
OTU domain-containing protein 7A

1

7

High-throughput

0.479

High

811958

EED
Polycomb protein EED

1

6

High-throughput

0.479

High

811960

CLD3
Claudin-3

1

20

Small-scale

0.479

High

811961

CLD8
Claudin-8

1

20

Small-scale

0.479

High

811962

CLD7
Claudin-7

1

20

Small-scale

0.479

High

811963

CLD6
Claudin-6

1

20

Small-scale

0.479

High

811964

KCNQ2
Potassium voltage-gated channel subfamily KQT member 2

1

20

High-throughput

0.479

High

777829

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High

811938

CAV3
Caveolin-3

1

8

High-throughput

0.445

High

811943

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

20

High-throughput

0.445

High

811959

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.445

High

313247

NOE1
Noelin

1

2

Small-scale

0.437

High

398145

CFAD
Complement factor D

1

3

High-throughput

0.437

High

811949

TAOK2
Serine/threonine-protein kinase TAO2

1

20

High-throughput

0.437

High

811956

CBPZ
Carboxypeptidase Z

1

11

High-throughput

0.437

High

811954

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025