HitPredict

Interactor 1: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Interactor 2: RB11A (P62491)
Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8)
Gene: RAB11A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	34079125, 29568061, 40437099
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0003925 - G protein activity GO:0005525 - GTP binding GO:0048227 - plasma membrane to endosome transport GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 216
+	Dm
		197081 RAB5_DROME (2-214): 4.07e-99: 288: 74.65		O18332_DROME (1-213): 5.76e-86: 254: 46.95
+	Hs
		976188 RAB1A_HUMAN (12-214): 4.51e-91: 267: 41.18		RB11A_HUMAN (1-216): 9e-94: 274: 100.00
+	Hs
		1370778 RAB8B_HUMAN (15-211): 9.23e-97: 281: 38.19		RAB1B_HUMAN (4-213): 3.27e-87: 257: 45.71
+	Hs
		900760 RAB5C_HUMAN (1-216): 8.5e-93: 272: 100.00		RAB1A_HUMAN (1-213): 2.83e-90: 265: 44.60
+	Zm
		77342 B4FAE1_MAIZE (14-215): 1.3e-93: 274: 41.38		B4FAE1_MAIZE (4-214): 5.98e-89: 262: 44.55
+	Hs
		981287 RAB1A_HUMAN (12-214): 4.51e-91: 267: 41.18		RB11B_HUMAN (1-216): 1.39e-90: 266: 90.37
+	Hs
		981254 RAB1A_HUMAN (12-214): 4.51e-91: 267: 41.18		RAB1A_HUMAN (1-213): 2.83e-90: 265: 44.60
+	Hs
		976185 RB11A_HUMAN (12-216): 1.17e-86: 256: 39.25		RB11A_HUMAN (1-216): 9e-94: 274: 100.00
+	Hs
		901029 RAB5C_HUMAN (1-216): 8.5e-93: 272: 100.00		RAB1B_HUMAN (4-213): 3.27e-87: 257: 45.71
+	Hs
		1155389 RAB1B_HUMAN (14-214): 2.66e-89: 262: 40.30		RB11B_HUMAN (1-216): 1.39e-90: 266: 90.37
+	Hs
		981357 RAB1A_HUMAN (12-214): 4.51e-91: 267: 41.18		RAB1B_HUMAN (4-213): 3.27e-87: 257: 45.71
+	Hs
		944972 RAB1A_HUMAN (12-214): 4.51e-91: 267: 41.18		RAB25_HUMAN (2-190): 8.35e-87: 256: 67.20
+	Mm
		981416 RAB1A_MOUSE (12-214): 4.51e-91: 267: 41.18		RAB1B_MOUSE (4-213): 9.45e-87: 256: 45.71
+	Zm
		78903 B4FJ62_MAIZE (13-216): 4.36e-87: 257: 37.74		B4FJ62_MAIZE (1-215): 1.84e-86: 256: 67.13
+	Hs
		944971 RB11A_HUMAN (12-216): 1.17e-86: 256: 39.25		RAB25_HUMAN (2-190): 8.35e-87: 256: 67.20
+	Hs
		981327 RAB1A_HUMAN (12-214): 4.51e-91: 267: 41.18		RAB2B_HUMAN (8-178): 6.74e-61: 191: 55.56
+	Hs
		1356536 RAB1B_HUMAN (14-214): 2.66e-89: 262: 40.30		RAB2B_HUMAN (8-178): 6.74e-61: 191: 55.56
+	Hs
		631371 RAB5A_HUMAN (1-216): 2.92e-88: 260: 86.57		RAB2B_HUMAN (8-178): 6.74e-61: 191: 55.56