HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 779
+	Ce
		136793 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		UNC89_CAEEL (146-660): 3.62e-58: 218: 12.35
+	Hs
		900445 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		925254 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		900428 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		900607 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		900901 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OSBL3_HUMAN (52-563): 4.71e-44: 173: 11.36
+	Hs
		900564 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Hs
		925241 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		925343 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Ce
		975574 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		Q23419_CAEEL (46-578): 5.81e-41: 163: 12.59
+	Mm
		925795 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		TIAM1_MOUSE (2-634): 2.04e-40: 163: 12.13
+	Rn
		88818 RAC1_RAT (1-193): 8.86e-80: 237: 57.22		D3ZWV8_RAT (2-634): 1.21e-39: 160: 11.65
+	Hs
		900771 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84
+	Hs
		900925 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA1_HUMAN (16-261): 3.76e-39: 151: 16.92
+	Hs
		900922 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		900634 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG22_HUMAN (29-181): 1.62e-33: 139: 26.95
+	Hs
		925394 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG22_HUMAN (29-181): 1.62e-33: 139: 26.95
+	Mm
		925805 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG22_MOUSE (33-181): 1.33e-31: 133: 25.77
+	Hs
		901085 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FARP1_HUMAN (6-167): 1.07e-24: 112: 17.96
+	Hs
		925603 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21