HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1116
+	Hs
		925629 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Ce
		136793 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		UNC89_CAEEL (727-1109): 1.99e-56: 217: 12.25
+	Mm
		925805 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG22_MOUSE (129-757): 1.01e-46: 181: 13.50
+	Rn
		88544 RHOA_RAT (1-193): 4.1e-81: 240: 99.48		D3ZCF5_RAT (11-202): 1.3e-44: 175: 17.07
+	Hs
		900820 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		925536 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Mm
		56825 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		SMUF2_MOUSE (12-202): 1.01e-43: 173: 14.85
+	Hs
		900634 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG22_HUMAN (139-751): 3.05e-43: 170: 15.09
+	Hs
		925394 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG22_HUMAN (139-751): 3.05e-43: 170: 15.09
+	Hs
		900925 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		900771 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		CNKR1_HUMAN (133-372): 1.73e-39: 159: 17.76
+	Hs
		925632 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		900607 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		900902 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		925616 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		900802 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		125308 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		925520 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		125349 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		125100 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51