Protein: CISD1
CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET)

Gene: CISD1
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9NZ45

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0006879 - intracellular iron ion homeostasis
GO:0010506 - regulation of autophagy
GO:0030170 - pyridoxal phosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1452976

CISD1
CDGSH iron-sulfur domain-containing protein 1

2

2

Small-scale

0.812

High

1327988

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

2

High-throughput

0.691

High

243146

PRKN
E3 ubiquitin-protein ligase parkin

2

1

Small-scale

0.584

High

1452985

MTCH2
Mitochondrial carrier homolog 2

2

2

High-throughput

0.571

High

1451731

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.559

High

1372407

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

1310475

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1350906

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1447720

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

1452986

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

976616

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.489

High

137834

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

275120

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

348776

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

376025

RASK
GTPase KRas

1

6

High-throughput

0.479

High

581334

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

901621

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

1125703

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

1147699

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.479

High

1312288

MIRO2
Mitochondrial Rho GTPase 2

1

16

High-throughput

0.479

High

1366604

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1403457

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1452977

MTCH1
Mitochondrial carrier homolog 1

1

2

High-throughput

0.479

High

1452981

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

106752

APRIO
Alternative prion protein

1

0

High-throughput

0.458

High

133809

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

245553

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

959275

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1278131

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

1356894

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.458

High

1382962

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

1397497

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1403813

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1450452

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

530470

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

653620

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

294438

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

374243

RASN
GTPase NRas

1

6

High-throughput

0.437

High

466494

RHOC
Rho-related GTP-binding protein RhoC

1

11

High-throughput

0.437

High

589887

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696706

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769363

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

910228

RND2
Rho-related GTP-binding protein RhoN

1

13

High-throughput

0.437

High

953709

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

High-throughput

0.437

High

955682

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.437

High

962563

RHOA
Transforming protein RhoA

1

12

High-throughput

0.437

High

1015852

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.437

High

1255852

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1434080

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1448029

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.437

High

1452984

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

722650

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.407

High

1452987

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

1

High-throughput

0.407

High

1327802

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.298

High

1326674

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

1452980

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.279

Low

1452983

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

0

High-throughput

0.279

Low

478234

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.251

Low

715815

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

831546

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

848112

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

0

High-throughput

0.249

Low

1140953

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1178431

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1229722

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1252997

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1386611

OPTN
Optineurin

1

0

High-throughput

0.249

Low

1404808

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

1429374

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1435379

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1452978

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1452979

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low

1452982

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.249

Low

923443

SC5A3
Sodium/myo-inositol cotransporter

1

0

High-throughput

0.232

Low

1063079

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025