HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 15199122, 31076518, 31685992, 24981860, 16878130, 23508102, 37689310, 36408368, 17041588, 15960974, 17925232, 21220120, 16603732, 20305087, 26186194, 25666610, 28514442, 27320920, 27705803, 28813667 and 16 others

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Identification Methods biochemical, affinity chromatography technology, pull down, proximity labelling technology, fluorescent resonance energy transfer, x-ray crystallography, unspecified method, isothermal titration calorimetry, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation and 2 others

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Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains WD40~WD40
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0035097 - histone methyltransferase complex
GO:0042393 - histone binding
GO:0044665 - MLL1/2 complex
and 4 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 334
Hs

1 538
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024