Protein: OSMR
Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)

Gene: OSMR
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q99650

Gene Ontology (top 5):
GO:0002675 - positive regulation of acute inflammatory response
GO:0004896 - cytokine receptor activity
GO:0005127 - ciliary neurotrophic factor receptor binding
GO:0005886 - plasma membrane
GO:0005900 - oncostatin-M receptor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658762

JAK1
Tyrosine-protein kinase JAK1

2

20

High-throughput

0.802

High

1406217

UBQL2
Ubiquilin-2

2

5

High-throughput

0.783

High

820541

IL6RB
Interleukin-6 receptor subunit beta

2

16

Small-scale

0.754

High

789001

TGFR2
TGF-beta receptor type-2

1

7

High-throughput

0.691

High

1270281

BT2A1
Butyrophilin subfamily 2 member A1

1

6

High-throughput

0.691

High

567766

ONCM
Oncostatin-M

1

4

Small-scale

0.647

High

909151

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.618

High

1406220

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

13

High-throughput

0.618

High

363762

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

411018

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

466431

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

953634

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

988647

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1406209

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1186029

SOAT
Sodium-dependent organic anion transporter

2

4

High-throughput

0.606

High

1406215

GPC5D
G-protein coupled receptor family C group 5 member D

2

3

High-throughput

0.606

High

1406227

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

4

High-throughput

0.601

High

484210

PGFRB
Platelet-derived growth factor receptor beta

1

11

High-throughput

0.575

High

596523

CTLA4
Cytotoxic T-lymphocyte protein 4

1

5

High-throughput

0.575

High

1177182

MICB
MHC class I polypeptide-related sequence B

1

10

High-throughput

0.575

High

895784

LHX2
LIM/homeobox protein Lhx2

2

5

High-throughput

0.553

High

1389493

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

7

High-throughput

0.553

High

1010095

DLK1
Protein delta homolog 1

2

11

High-throughput

0.549

High

1406219

FBX2
F-box only protein 2

2

15

High-throughput

0.549

High

1406226

SRPRB
Signal recognition particle receptor subunit beta

2

5

High-throughput

0.549

High

166023

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.536

High

190468

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.536

High

1119653

KCNC3
Voltage-gated potassium channel KCNC3

1

4

High-throughput

0.536

High

1249957

I20RB
Interleukin-20 receptor subunit beta

1

5

High-throughput

0.536

High

1287180

T150A
Transmembrane protein 150A

1

2

High-throughput

0.536

High

1334449

RELL2
RELT-like protein 2

1

3

High-throughput

0.536

High

1359411

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

2

High-throughput

0.536

High

1381817

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

5

High-throughput

0.536

High

1391379

MRAP2
Melanocortin-2 receptor accessory protein 2

1

3

High-throughput

0.536

High

1406216

GPC5B
G-protein coupled receptor family C group 5 member B

1

3

High-throughput

0.536

High

1406222

PCDB3
Protocadherin beta-3

1

17

High-throughput

0.536

High

1406224

PCDA8
Protocadherin alpha-8

1

16

High-throughput

0.536

High

1406206

KCJ15
ATP-sensitive inward rectifier potassium channel 15

1

1

High-throughput

0.515

High

1212110

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.513

High

1406208

TM204
Transmembrane protein 204

1

0

High-throughput

0.513

High

409050

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.508

High

275726

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

1

Small-scale

0.489

High

347885

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.489

High

702668

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

1

Small-scale

0.489

High

801490

HSPA9
Stress-70 protein, mitochondrial

1

8

Small-scale

0.489

High

1293993

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

1

High-throughput

0.489

High

1358790

ZDH19
Palmitoyltransferase ZDHHC19

1

4

High-throughput

0.489

High

1358802

RN133
E3 ubiquitin-protein ligase RNF133

1

7

High-throughput

0.489

High

1371844

CUL5
Cullin-5

1

5

High-throughput

0.489

High

1406210

TM231
Transmembrane protein 231

1

2

High-throughput

0.489

High

1406211

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

218675

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

903241

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

3

High-throughput

0.479

High

1406207

ZFY21
Zinc finger FYVE domain-containing protein 21

1

2

High-throughput

0.470

High

212474

SPIT2
Kunitz-type protease inhibitor 2

1

5

High-throughput

0.445

High

388445

B3AT
Band 3 anion transport protein

1

5

High-throughput

0.445

High

480884

LEG1
Galectin-1

1

20

High-throughput

0.445

High

564271

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

669356

ACKR3
Atypical chemokine receptor 3

1

8

High-throughput

0.445

High

876438

EAA4
Excitatory amino acid transporter 4

1

6

High-throughput

0.445

High

880189

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.445

High

1156943

CNGA3
Cyclic nucleotide-gated channel alpha-3

1

12

High-throughput

0.445

High

1244109

TMM88
Transmembrane protein 88

1

1

High-throughput

0.445

High

1256787

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

1

High-throughput

0.445

High

1273793

NIPA1
Magnesium transporter NIPA1

1

5

High-throughput

0.445

High

1310932

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

2

High-throughput

0.445

High

1330494

LRC52
Leucine-rich repeat-containing protein 52

1

13

High-throughput

0.445

High

1406223

PCDG5
Protocadherin gamma-A5

1

18

High-throughput

0.445

High

1406225

PCDA3
Protocadherin alpha-3

1

18

High-throughput

0.445

High

539739

ACHB
Acetylcholine receptor subunit beta

1

0

High-throughput

0.426

High

1399048

TMM74
Transmembrane protein 74

1

0

High-throughput

0.426

High

73846

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

3

High-throughput

0.407

High

221648

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

Small-scale

0.407

High

1406212

ZDH11
Palmitoyltransferase ZDHHC11

1

8

High-throughput

0.407

High

1406214

FBX6
F-box only protein 6

1

15

High-throughput

0.407

High

1406221

ZDHC9
Palmitoyltransferase ZDHHC9

1

4

High-throughput

0.407

High

1126347

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

2

0

High-throughput

0.313

High

1291824

T200A
Transmembrane protein 200A

1

0

High-throughput

0.279

Low

1406218

ATIF1
ATPase inhibitor, mitochondrial

1

0

Small-scale

0.249

Low

219825

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.232

Low

1225728

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

0

High-throughput

0.232

Low

1406213

POPD2
Popeye domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025