HitPredict

Interactor 1: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38697112
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 486 Hs			1 1233
+	Mm
		1423811 MECP2_MOUSE (1-486): 5.36e-112: 341: 94.44		SMC1A_MOUSE (1-1233): 6.24e-128: 426: 99.84
+	Hs
		905299 MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Mm
		1423826 MECP2_MOUSE (1-486): 5.36e-112: 341: 94.44		SMC3_MOUSE (3-1229): 4.92e-69: 256: 15.78
+	Hs
		1130128 TITIN_HUMAN (240-472): 1.29e-12: 72.8: 19.57		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		1130076 NIPBL_HUMAN (72-455): 1.96e-09: 62.4: 14.06		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		334065 TITIN_HUMAN (240-472): 1.29e-12: 72.8: 19.57		SMC2_HUMAN (3-1214): 4.82e-78: 283: 18.14
+	Hs
		1361939 TITIN_HUMAN (240-472): 1.29e-12: 72.8: 19.57		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Hs
		1235693 NIPBL_HUMAN (72-455): 1.96e-09: 62.4: 14.06		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78