HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: RASF8 (Q8NHQ8)
Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)
Gene: RASSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.50	0.660

Property	Details
Experiments	24366813, 26186194, 28514442, 28330616, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 419
+	Hs
		277406 PP1A_HUMAN (1-330): 0: 614: 100.00		RASF9_HUMAN (2-411): 2.1e-120: 358: 21.45
+	Hs
		737935 PP1G_HUMAN (1-330): 0: 579: 90.66		RASF8_HUMAN (1-419): 8.08e-125: 369: 100.00
+	Hs
		277404 PP1G_HUMAN (1-330): 0: 579: 90.66		RASF9_HUMAN (2-411): 2.1e-120: 358: 21.45
+	Hs
		905884 PP1A_HUMAN (1-330): 0: 614: 100.00		ASPP2_HUMAN (1-406): 1.62e-99: 322: 15.46
+	Mm
		93784 PP1A_MOUSE (1-330): 0: 614: 99.70		E9QJU8_MOUSE (1-406): 1.33e-97: 317: 14.98
+	Hs
		277407 PP1B_HUMAN (1-330): 0: 568: 87.88		RASF9_HUMAN (2-411): 2.1e-120: 358: 21.45
+	Hs
		63639 PP1A_HUMAN (1-330): 0: 614: 100.00		RASFA_HUMAN (2-410): 1.25e-99: 308: 14.66
+	Mm
		906278 PP1A_MOUSE (1-330): 0: 614: 99.70		ASPP1_MOUSE (1-399): 2.12e-93: 305: 15.73
+	Hs
		906081 PP1A_HUMAN (1-330): 0: 614: 100.00		ASPP1_HUMAN (1-399): 4.08e-87: 288: 14.99
+	Hs
		737795 PP1G_HUMAN (1-330): 0: 579: 90.66		ASPP2_HUMAN (1-406): 1.62e-99: 322: 15.46
+	Hs
		906447 PP1B_HUMAN (1-330): 0: 568: 87.88		ASPP2_HUMAN (1-406): 1.62e-99: 322: 15.46
+	Hs
		737981 PP1G_HUMAN (1-330): 0: 579: 90.66		ASPP1_HUMAN (1-399): 4.08e-87: 288: 14.99
+	Hs
		905842 PP1A_HUMAN (1-330): 0: 614: 100.00		RASF7_HUMAN (1-405): 1.95e-77: 246: 33.42
+	Hs
		905849 PP1A_HUMAN (1-330): 0: 614: 100.00		Q05BL1_HUMAN (84-406): 4.4e-64: 224: 12.16
+	Hs
		737754 PP1G_HUMAN (1-330): 0: 579: 90.66		RASF7_HUMAN (1-405): 1.95e-77: 246: 33.42
+	Hs
		906419 PP1B_HUMAN (1-330): 0: 568: 87.88		RASF7_HUMAN (1-405): 1.95e-77: 246: 33.42
+	Hs
		737760 PP1G_HUMAN (1-330): 0: 579: 90.66		Q05BL1_HUMAN (84-406): 4.4e-64: 224: 12.16
+	Hs
		906424 PP1B_HUMAN (1-330): 0: 568: 87.88		Q05BL1_HUMAN (84-406): 4.4e-64: 224: 12.16
+	Dm
		819225 PP11_DROME (4-330): 0: 573: 87.77		Q9VBP2_DROME (1-81): 8.78e-28: 117: 69.14
+	Dm
		819242 PP11_DROME (4-330): 0: 573: 87.77		Q9W2J2_DROME (137-336): 1.06e-10: 65.8: 9.35