HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	10194355, 33537097, 34591612, 19094064, 26186194, 27880917, 28514442, 28330616, 33961781, 22321011, 15231748, 25593058, 25785436
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, Metallophos~PDZ_5, PDZ~STPPase_N, PDZ_5~STPPase_N
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0008157 - protein phosphatase 1 binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 817
+	Rn
		192519 PP1A_RAT (1-330): 0: 614: 100.00		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Mm
		906288 PP1A_MOUSE (1-330): 0: 614: 99.70		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Hs
		906197 PP1A_HUMAN (1-330): 0: 614: 100.00		NEB1_HUMAN (1-817): 2.29e-110: 364: 46.47
+	Hs
		737997 PP1G_HUMAN (1-330): 0: 579: 90.66		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Rn
		192521 PP1G_RAT (1-330): 0: 579: 90.66		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Mm
		926545 PP1G_MOUSE (1-330): 0: 579: 90.66		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Rn
		192520 PP1B_RAT (1-330): 0: 568: 87.88		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Hs
		738120 PP1G_HUMAN (1-330): 0: 579: 90.66		NEB1_HUMAN (1-817): 2.29e-110: 364: 46.47
+	Rn
		193534 PP1G_RAT (1-330): 0: 579: 90.66		NEB1_RAT (1-817): 1.22e-104: 349: 46.38
+	Rn
		193533 PP1B_RAT (1-330): 0: 568: 87.88		NEB1_RAT (1-817): 1.22e-104: 349: 46.38
+	Hs
		906059 PP1A_HUMAN (1-330): 0: 614: 100.00		DLG3_HUMAN (154-707): 4.39e-44: 173: 12.27
+	Hs
		906094 PP1A_HUMAN (1-330): 0: 614: 100.00		ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02
+	Mm
		926531 PP1G_MOUSE (1-330): 0: 579: 90.66		DLG3_MOUSE (154-707): 1.11e-45: 178: 12.34
+	Hs
		906031 PP1A_HUMAN (1-330): 0: 614: 100.00		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		737994 PP1G_HUMAN (1-330): 0: 579: 90.66		ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02
+	Hs
		905921 PP1A_HUMAN (1-330): 0: 614: 100.00		DLG2_HUMAN (419-621): 7.73e-28: 122: 20.69
+	Mm
		906274 PP1A_MOUSE (1-330): 0: 614: 99.70		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		905890 PP1A_HUMAN (1-330): 0: 614: 100.00		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Hs
		737775 PP1G_HUMAN (1-330): 0: 579: 90.66		DLG1_HUMAN (435-691): 6e-19: 94.1: 15.04
+	Hs
		737799 PP1G_HUMAN (1-330): 0: 579: 90.66		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15