Protein: SAE2
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)

Gene: SAE2, UBA2
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9UBT2

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016740 - transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1353967

SAE1
SUMO-activating enzyme subunit 1

17

12

Small-scale

0.987

High

930429

UBC9
SUMO-conjugating enzyme UBC9

15

20

Small-scale

0.986

High

928217

SUMO1
Small ubiquitin-related modifier 1

10

9

Small-scale

0.975

High

902787

SUMO2
Small ubiquitin-related modifier 2

3

9

Small-scale

0.834

High

476506

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

15

Small-scale

0.778

High

1354308

SAE2
SUMO-activating enzyme subunit 2

2

10

Small-scale

0.778

High

228963

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.754

High

102176

SUMO5
Small ubiquitin-related modifier 5

1

9

High-throughput

0.665

High

171508

UBD
Ubiquitin D

1

15

Small-scale

0.647

High

1079620

NEDD8
NEDD8

1

5

Small-scale

0.647

High

879160

SUMO3
Small ubiquitin-related modifier 3

1

9

Small-scale

0.618

High

909273

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1307218

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.618

High

1336178

CPNE5
Copine-5

2

1

High-throughput

0.574

High

1135996

CE162
Centrosomal protein of 162 kDa

2

1

High-throughput

0.571

High

260044

TBCA
Tubulin-specific chaperone A

2

0

High-throughput

0.559

High

983938

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

1076561

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.536

High

1255610

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

1305845

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

272751

OFD1
Centriole and centriolar satellite protein OFD1

2

1

High-throughput

0.521

High

1202278

LCA5
Lebercilin

2

1

High-throughput

0.521

High

1282360

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.516

High

154259

CHK1
Serine/threonine-protein kinase Chk1

1

2

Small-scale

0.501

High

976523

ERCC6
DNA excision repair protein ERCC-6

1

2

High-throughput

0.501

High

1354314

SAR1B
Small COPII coat GTPase SAR1B

1

3

High-throughput

0.489

High

1188071

SETX
Probable helicase senataxin

1

0

Small-scale

0.486

High

1304257

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.486

High

838331

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

1241052

SERB1
SERPINE1 mRNA-binding protein 1

1

3

Small-scale

0.481

High

794573

ETV4
ETS translocation variant 4

1

0

Small-scale

0.480

High

245050

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

324660

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

339081

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

385659

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

387658

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

455965

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

553961

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

570146

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

652502

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

721680

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

780257

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

875395

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

1029977

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

1042745

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1050289

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1172110

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1231360

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

1267219

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1272668

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

1304954

NECD
Necdin

1

2

High-throughput

0.479

High

1331530

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1348879

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1354310

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1354311

HERC5
E3 ISG15--protein ligase HERC5

1

11

Small-scale

0.479

High

1354312

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.479

High

1354313

TRAF6
TNF receptor-associated factor 6

1

4

High-throughput

0.479

High

1151282

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

154876

TCRG1
Transcription elongation regulator 1

1

0

High-throughput

0.458

High

178029

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

181360

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.458

High

617695

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

824493

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

834860

RBP2
E3 SUMO-protein ligase RanBP2

1

0

Small-scale

0.458

High

900084

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

975086

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1027305

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1062207

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

1116781

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.458

High

1330535

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1345447

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1348363

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1354309

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

529850

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

718274

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

1241777

RN169
E3 ubiquitin-protein ligase RNF169

1

2

Small-scale

0.445

High

1318881

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1255230

BRX1
Ribosome biogenesis protein BRX1 homolog

1

1

High-throughput

0.439

High

123750

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.437

High

983261

UBE3A
Ubiquitin-protein ligase E3A

1

12

High-throughput

0.437

High

1318317

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

Small-scale

0.437

High

1346240

Q9NUW4
Ribosome biogenesis protein BRX1 homolog

1

1

High-throughput

0.417

High

831759

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

1316793

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.305

High

1316031

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

1291026

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.261

Low

354590

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

456957

FURIN
Furin

1

0

High-throughput

0.249

Low

617915

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.249

Low

790691

WASP
Actin nucleation-promoting factor WAS

1

0

Small-scale

0.249

Low

1313092

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

1343201

GPC5C
G-protein coupled receptor family C group 5 member C

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024