Protein: ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial (EC 1.2.1.-) (EC 1.2.1.4) (K(+)-activated acetaldehyde dehydrogenase) (K(+)-ACDH)

Gene: ALDH4, ALD4
Organism: Saccharomyces cerevisiae S288C
Interactions: 135
UniProt ID: P46367

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0006067 - ethanol metabolic process
GO:0006629 - lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

856544

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

2

14

Small-scale

0.768

High

510602

HSP77
Import motor subunit, mitochondrial

3

5

High-throughput

0.640

High

604962

MDHM
Malate dehydrogenase, mitochondrial

3

3

Small-scale

0.640

High

817496

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

15

High-throughput

0.618

High

727132

HS104
Heat shock protein 104

3

3

Small-scale

0.585

High

367063

ATPB
ATP synthase subunit beta, mitochondrial

2

3

High-throughput

0.584

High

452927

ATPA
ATP synthase subunit alpha, mitochondrial

2

3

High-throughput

0.584

High

622376

ACON
Aconitate hydratase, mitochondrial

2

3

High-throughput

0.584

High

626791

HSP60
Heat shock protein 60, mitochondrial

2

4

High-throughput

0.584

High

781408

MIC60
MICOS complex subunit MIC60

2

1

High-throughput

0.584

High

752421

HSP78
Heat shock protein 78, mitochondrial

2

3

High-throughput

0.571

High

808517

TEM1
Protein TEM1

2

3

High-throughput

0.543

High

670863

SIS1
Protein SIS1

2

4

High-throughput

0.521

High

836760

MPG1
Mannose-1-phosphate guanyltransferase

2

2

High-throughput

0.521

High

545333

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.504

High

628077

FKBP
FK506-binding protein 1

1

3

High-throughput

0.500

High

358412

ADH2
Alcohol dehydrogenase 2

1

2

High-throughput

0.479

High

394055

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

417133

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.479

High

452675

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

2

High-throughput

0.479

High

469998

FUMH
Fumarate hydratase, mitochondrial

1

2

High-throughput

0.479

High

522352

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

635972

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

6

High-throughput

0.479

High

642152

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

646606

TRX1
Thioredoxin-1

1

4

High-throughput

0.479

High

654606

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

673512

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

3

High-throughput

0.479

High

677880

ADY2
Accumulation of dyads protein 2

1

1

High-throughput

0.479

High

679817

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

680598

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

1

High-throughput

0.479

High

685105

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

694475

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

701543

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.479

High

705648

HIBCH
Small ribosomal subunit protein mS47

1

1

High-throughput

0.479

High

746998

PREP
Presequence protease, mitochondrial

1

4

High-throughput

0.479

High

747699

ATO2
Ammonia transport outward protein 2

1

1

High-throughput

0.479

High

763456

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.479

High

823430

MPM1
Mitochondrial peculiar membrane protein 1

1

1

High-throughput

0.479

High

835595

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

1

High-throughput

0.479

High

844372

ETFB
Probable electron transfer flavoprotein subunit beta

1

1

High-throughput

0.479

High

850062

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.479

High

856548

ALAT1
Alanine aminotransferase, mitochondrial

1

2

High-throughput

0.479

High

856550

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

856551

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

856555

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

856558

ABF2
ARS-binding factor 2, mitochondrial

1

4

Small-scale

0.479

High

856559

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.479

High

856566

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

856568

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

15

High-throughput

0.479

High

856575

SMC6
Structural maintenance of chromosomes protein 6

1

3

High-throughput

0.479

High

360997

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.458

High

382938

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

397574

SCE1
Intron-encoded endonuclease I-SceI

1

0

High-throughput

0.458

High

439586

LEU1
2-isopropylmalate synthase

1

0

High-throughput

0.458

High

746877

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

753005

XPOT
Exportin-T

1

0

High-throughput

0.458

High

778219

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.458

High

800351

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

804812

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

818618

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

856547

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

856557

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.458

High

856563

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

449353

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

1

High-throughput

0.457

High

459116

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.457

High

574701

KSS1
Mitogen-activated protein kinase KSS1

1

3

High-throughput

0.457

High

617405

GBB
Guanine nucleotide-binding protein subunit beta

1

3

High-throughput

0.457

High

625023

PRP6
Pre-mRNA-splicing factor 6

1

4

High-throughput

0.457

High

633482

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.457

High

671491

RAD57
DNA repair protein RAD57

1

1

High-throughput

0.457

High

745445

KU70
ATP-dependent DNA helicase II subunit 1

1

2

High-throughput

0.457

High

746348

RAD54
DNA repair and recombination protein RAD54

1

4

High-throughput

0.457

High

800958

RFC3
Replication factor C subunit 3

1

2

High-throughput

0.457

High

816139

HAT2
Histone acetyltransferase type B subunit 2

1

6

High-throughput

0.457

High

823184

RAD26
DNA repair and recombination protein RAD26

1

4

High-throughput

0.457

High

836049

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.457

High

856549

RPN14
26S proteasome regulatory subunit RPN14

1

4

High-throughput

0.457

High

856556

2ABA
Protein phosphatase PP2A regulatory subunit B

1

1

High-throughput

0.457

High

856560

WDR59
Maintenance of telomere capping protein 5

1

9

High-throughput

0.457

High

856564

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.457

High

856565

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

856567

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

3

High-throughput

0.457

High

856573

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

453659

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

527009

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

410201

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433708

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

435180

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

439371

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.437

High

441983

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

454743

KAPR
cAMP-dependent protein kinase regulatory subunit

1

2

Small-scale

0.437

High

477580

MYO1
Myosin-1

1

1

Small-scale

0.437

High

486228

TBA1
Tubulin alpha-1 chain

1

5

High-throughput

0.437

High

486482

TBA3
Tubulin alpha-3 chain

1

5

High-throughput

0.437

High

504278

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

558779

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

568738

RSR1
Ras-related protein RSR1

1

1

High-throughput

0.437

High

645456

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.437

High

707454

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

745790

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.437

High

747920

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

792112

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.437

High

795064

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

803595

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.437

High

812427

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

856553

HST2
NAD-dependent protein deacetylase HST2

1

7

High-throughput

0.437

High

856554

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

856574

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

386761

TBB
Tubulin beta chain

1

3

High-throughput

0.407

High

524345

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.407

High

741835

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.407

High

856545

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

796093

IMB2
Importin subunit beta-2

2

0

High-throughput

0.318

High

449142

CALM
Calmodulin

1

0

High-throughput

0.261

Low

575284

RAD9
DNA repair protein RAD9

1

0

High-throughput

0.261

Low

575351

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.261

Low

645946

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.261

Low

666692

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

735267

KNS1
Dual specificity protein kinase KNS1

1

0

High-throughput

0.261

Low

737327

CDC12
Cell division control protein 12

1

0

High-throughput

0.261

Low

805551

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

0

High-throughput

0.261

Low

856552

SSK2
MAP kinase kinase kinase SSK2

1

0

High-throughput

0.261

Low

856561

YD131
F-box protein YDR131C

1

0

High-throughput

0.261

Low

856562

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.261

Low

856572

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

365092

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.249

Low

735041

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

763928

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

764104

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

856546

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

856569

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

856570

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

801725

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.232

Low

856571

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025